Investigations of Modified Functional Connectivity at Rest in Drug-Resistant Temporal Lobe Epilepsy Patients

this experimental study patients with temporal lobe epilepsy and controls have been compared for functional connectivity (FC) using resting-state functional magnetic resonance imaging (rs-fMRI). This research work examines the alterations to better understand the issues with brain activity of individuals suffering from Temporal Lobe epilepsy (TLE), during the rest state. The major objective of this study is to investigate FC-related alterations in the resting state to fully comprehend the complex nature of epilepsy. It is observed that FC gets altered in specific regions in the case of patients suffering from left-sided Temporal Lobe Epilepsy and right-sided Temporal Lobe Epilepsy as compared to controls. Using rs-fMRI, it is found that the right-sided TLE patient group had altered hippocampus networks than the control right-side group. There are considerable differences between the left and right areas of control and the groups with mesial temporal hippocampal sclerosis on the left and right sides. When compared to control left brain regions, the left-side TLE group exhibits reduced connection between the anterior cingulate gyrus and the affected hippocampus and increased regional connectivity between the affected hippocampus and the default posterior cingulate cortex region.