Mucositis and Infection in Hematology Patients

被引：8

作者：

Blijlevens, Nicole M. A. ^{[1
]}

de Mooij, Charlotte E. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen Med Ctr, Dept Haematol, POB 9101, NL-6500 HB Nijmegen, Netherlands

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 11期

关键词：

mucositis; inflammation; bacteremia; infection; chemotherapy; neutropenia; MUCOSAL BARRIER INJURY; BLOOD-STREAM INFECTION; INDUCED ORAL MUCOSITIS; STEM-CELL TRANSPLANT; HIGH-DOSE MELPHALAN; DOUBLE-BLIND; INTESTINAL MICROBIOTA; CANCER-PATIENTS; GUT MICROBIOTA; ANTIMICROBIAL THERAPY;

D O I：

10.3390/ijms24119592

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Survival in patients with hematological malignancies has improved over the years, both due to major developments in anticancer treatment, as well as in supportive care. Nevertheless, important and debilitating complications of intensive treatment regimens still frequently occur, including mucositis, fever and bloodstream infections. Exploring potential interacting mechanisms and directed therapies to counteract mucosal barrier injury is of the utmost importance if we are to continue to improve care for this increasingly growing patient population. In this perspective, I highlight recent advances in our understanding of the relation of mucositis and infection.

引用

页数：18

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