Metastasis suppressor genes and their role in the tumor microenvironment

被引：3

作者：

Megino-Luque, Cristina ^{[1
]}

Bravo-Cordero, Jose Javier ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Med, Div Hematol & Oncol, New York, NY 10029 USA

来源：

CANCER AND METASTASIS REVIEWS | 2023年 / 42卷 / 04期

关键词：

Metastasis; Tumor microenvironment; Cancer; Metastasis suppresor genes; LUNG METASTASIS; CELL-MIGRATION; ACTIN DYNAMICS; RHO GTPASES; DORMANCY; CANCER; RHOGDI2; COLONIZATION; DETERMINANT; PROGRESSION;

D O I：

10.1007/s10555-023-10155-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within this complex process, several genes have been identified as metastasis suppressors, playing a role in the inhibition of metastasis. Interestingly, some of these genes have been shown to also play a role in regulating the tumor microenvironment. In this review, we comment on the recent developments in the biology of metastasis suppressor genes and their crosstalk with the microenvironment.

引用

页码：1147 / 1154

页数：8

共 82 条

[1]

Aguirre-Ghiso JA, 2003, CANCER RES, V63, P1684

[2] An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis Suppression [J].

Ahmed, Mansoor ;

Sottnik, Joseph L. ;

Dancik, Garrett M. ;

Sahu, Divya ;

Hansel, Donna E. ;

Theodorescu, Dan ;

Schwartz, Martin A. .

CANCER CELL, 2016, 30 (03) :432-443

[3] EMT: 2016 [J].

Angela Nieto, M. ;

Huang, Ruby Yun-Ju ;

Jackson, Rebecca A. ;

Thiery, Jean Paul .

CELL, 2016, 166 (01) :21-45

[4] Metastasis suppressor genes - From gene identification to protein function and regulation [J].

Berger, JC ;

Vander Griend, DJ ;

Robinson, VL ;

Hickson, JA ;

Rinker-Schaeffer, CW .

CANCER BIOLOGY & THERAPY, 2005, 4 (08) :805-812

[5] Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells [J].

Borriello, Lucia ;

Coste, Anouchka ;

Traub, Brian ;

Sharma, Ved P. ;

Karagiannis, George S. ;

Lin, Yu ;

Wang, Yarong ;

Ye, Xianjun ;

Duran, Camille L. ;

Chen, Xiaoming ;

Friedman, Madeline ;

Sosa, Maria Soledad ;

Sun, Dan ;

Dalla, Erica ;

Singh, Deepak K. ;

Oktay, Maja H. ;

Aguirre-Ghiso, Julio A. ;

Condeelis, John S. ;

Entenberg, David .

NATURE COMMUNICATIONS, 2022, 13 (01)

[6] Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy [J].

Boyerinas, Benjamin ;

Zafrir, Maya ;

Yesilkanal, Ali E. ;

Price, Trevor T. ;

Hyjek, Elizabeth M. ;

Sipkins, Dorothy A. .

BLOOD, 2013, 121 (24) :4821-4831

[7] TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [J].

Bragado, Paloma ;

Estrada, Yeriel ;

Parikh, Falguni ;

Krause, Sarah ;

Capobianco, Carla ;

Farina, Hernan G. ;

Schewe, Denis M. ;

Aguirre-Ghiso, Julio A. .

NATURE CELL BIOLOGY, 2013, 15 (11) :1351-U210

[8] A novel high-content analysis tool reveals Rab8-driven cytoskeletal reorganization through Rho GTPases, calpain and MT1-MMP [J].

Bravo-Cordero, Jose J. ;

Cordani, Marco ;

Soriano, Silvia F. ;

Diez, Begona ;

Munoz-Agudo, Carmen ;

Casanova-Acebes, Maria ;

Boullosa, Cesar ;

Guadamillas, Marta C. ;

Ezkurdia, Iakes ;

Gonzalez-Pisano, David ;

del Pozo, Miguel A. ;

Montoya, Maria C. .

JOURNAL OF CELL SCIENCE, 2016, 129 (08) :1734-1749

[9] Directed cell invasion and migration during metastasis [J].

Bravo-Cordero, Jose Javier ;

Hodgson, Louis ;

Condeelis, John .

CURRENT OPINION IN CELL BIOLOGY, 2012, 24 (02) :277-283

[10] Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment [J].

Butturini, Elena ;

de Prati, Alessandra Carcereri ;

Boriero, Diana ;

Mariotto, Sofia .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (17)

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