Efficacy and safety of leuprorelin 3-month depot (11.25 mg) for idiopathic central precocious puberty treatment of Chinese girls: a single-center retrospective study

Objectives: This study aimed to evaluate the efficacy and safety of 3-month leuprorelin acetate (3-month LA, 11.25 mg) for the treatment of idiopathic central precocious puberty (ICPP) in Chinese girls.Methods: We conducted a single-center retrospective study in China on 28 girls with ICPP who received at least one year of 3-month LA treatment. Data from anthropom-etry, biochemistry, bone age (BA), and pelvic ultrasonog-raphy were assessed before and every 6 months during medication.Results: At CPP diagnosis, the mean chronological age (CA) was 7.8 +/- 0.8 years, with bone age advancement (BA-CA) of 1.5 +/- 0.8 years. After treatment initiation, growth velocity decreased significantly from 8.5 +/- 1.6 cm/year to 5.8 +/- 1.1 cm/year at month 12 (p<0.001). GnRH-stimulated peak LH <= 3IU/L, the primary efficacy criterion, was observed in 27 out of 28 (96.4 %) children at month 3. Basal estradiol <20 pg/mL was ach-ieved by all 28 girls (100 %) at month 6 and remained stable at month 12. Basal FSH decreased from 4.1 +/- 3.5 to 1.7 +/- 0.9 (p<0.001), and basal LH was also significantly reduced from 3.3 +/- 6.5 to 0.7 +/- 0.8 (p=0.035) at month 12. The mean predicted adult height (PAH) at treatment initiation was 152.7 +/- 5.8 cm, it increased significantly to 157.5 +/- 5.5 cm (p=0.007) after one-year treatment. Pubertal development was slowed in most patients, and in some cases, it was even reversed. Only one patient (3.6 %) reported local intolerance.Conclusions: Three-month leuprorelin acetate is a safe and effective treatment for suppressing the pituitary-gonadal axis and restoring impaired adult height in Chinese girls.