Enhanced Renal Carcinoma Treatment via Synergistic Photothermal/Photodynamic Therapy Using Hittorf's Phosphorus-Decorated Polymeric Carbon Nitride Heterostructure

被引：0

作者：

Guan, Chen ^{[1
]}

Li, Chenyu ^{[1
]}

Yang, Chengyu ^{[1
]}

Yang, Dongjiang ^{[2
]}

Zhang, Lixue ^{[3
]}

Xu, Lingyu ^{[1
]}

Liu, Ke ^{[2
]}

Zhang, Ningxin ^{[1
]}

Li, Tianyang ^{[1
]}

Song, Zhuo ^{[1
]}

Che, Lin ^{[1
]}

Wang, Yanfei ^{[1
]}

Zhang, Liwei ^{[4
,5
]}

Li, Daohao ^{[2
]}

Zhu, Yukun ^{[2
]}

Xu, Yan ^{[1
]}

机构：

[1] Qingdao Univ, Dept Nephrol, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266003, Peoples R China

[2] Qingdao Univ, Sch Environm Sci & Engn, State Key Lab Biofibers & Ecotext, 308 Ningxia Rd, Qingdao 266071, Peoples R China

[3] Qingdao Univ, Coll Chem & Chem Engn, Collaborat Innovat Ctr Hydrogen Energy Key Mat & T, Qingdao 266071, Peoples R China

[4] Helmholtz Ctr Munich, Inst Diabet & Regenerat Res, Helmholtz Diabet Ctr, D-85764 Neuherberg, Germany

[5] Ludwig Maximilians Univ Munchen, Med Klin & Poliklin 4, D-80339 Munich, Germany

来源：

ADVANCED OPTICAL MATERIALS | 2024年 / 12卷 / 14期

基金：

中国国家自然科学基金;

关键词：

clear cell renal cell carcinoma; Hittorf's phosphorus; mild photothermal therapy; photodynamic therapy; PHOTOTHERMAL THERAPY; CELL CARCINOMA; PHOTODYNAMIC THERAPY; TUMOR; NANOPARTICLES; NANOMATERIALS; RESISTANCE;

D O I：

10.1002/adom.202303318

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Nanostructured heterojunctions offer a promising solution to overcome the limitations of narrow absorption spectra, limited penetration depths, and potential harm to healthy cells in phototherapy for clear cell renal cell carcinoma (ccRCC) treatment with nanomaterials. In this study, a heterostructure (PCN@HP) by decorating Hittorf's phosphorus nanorods onto biocompatible polymeric carbon nitride (PCN), enabling excitation by NIR light is designed. Compared with PCN and HP alone, the synthesized heterostructure generated localized heat upon broad absorption spectra of irradiation, boosting charge migration and separation, generating cytotoxic reactive oxygen species (ROS). Then, via in vitro and in vivo experiments, it is confirmed that the NIR-mediated PCN@HP heterojunction is a safe and effective approach for synchronous photothermal and photodynamic therapy treatment of ccRCC. Collectively, the PCN@HP heterojunction holds great potential as a non-invasive synergistic, dual-mode therapeutic nanomedicine for efficient tumor nano-therapy. A heterostructure of Hittorf's phosphorus (HP) nanorods decorated with polymeric carbon nitride is designed. This heterostructure exhibits an enhanced antitumor effect via the combination of photothermal therapy (PTT) and photodynamic therapy (PDT) involving types I and II. This system can serve as a prospective imaging-guided, real-time, non-invasive, safe, and synergistic dual-mode therapeutic nanomedicine for efficient tumor nano-therapy. image

引用

页数：11

共 2 条

[1] Red Phosphorus Decorated TiO2 Nanorod Mediated Photodynamic and Photothermal Therapy for Renal Cell Carcinoma
Yang, Chengyu
Zhu, Yukun
Li, Daohao
Liu, Yiming
Guan, Chen
Man, Xiaofei
Zhang, Shuchao
Zhang, Lixue
Yang, Dongjiang
Xu, Yan
SMALL, 2021, 17 (30)
[2] Carbon-Dot-Decorated Carbon Nitride Nanoparticles for Enhanced Photodynamic Therapy against Hypoxic Tumor via Water Splitting
Zheng, Di-Wei
Li, Bin
Li, Chu-Xin
Fan, Jin-Xuan
Lei, Qi
Li, Cao
Xu, Zushun
Zhang, Xian-Zheng
ACS NANO, 2016, 10 (09) : 8715 - 8722

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