Costunolide ameliorates angiotensin II-induced atrial inflammation and fibrosis by regulating mitochondrial function and oxidative stress in mice: A possible therapeutic approach for atrial fibrillation

被引:2
作者
Liu, Yushu [1 ]
Wang, Dong [2 ]
Jin, Yimin [3 ]
Sun, Guifang [4 ]
Lou, Qi [5 ]
Wang, Hong [5 ]
Li, Weimin [4 ]
机构
[1] Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
[2] Mudanjiang Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Mudanjiang, Peoples R China
[3] Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
[4] Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
[5] Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
关键词
Angiotensin II; Atrial fibrillation; Inflammation; Fibrosis; Mitochondrial function; Oxidative stress; METABOLISM; EXPRESSION; APOPTOSIS; RECEPTOR; HEART;
D O I
10.1016/j.mvr.2023.104600
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Atrial fibrillation (AF) is a cardiac disease characterized by disordered atrial electrical activity. Atrial inflammation and fibrosis are involved in AF progression. Costunolide (COS) is a sesquiterpene lactone containing antiinflammatory and anti-fibrotic activities. This study aims to explore the underlying mechanisms by which COS protects against AF. Male C57BL/6 mice (8- to 10-week-old) were infused with angiotensin (Ang) II for 3 weeks. Meanwhile, different doses of COS (COS-L: 10 mg/kg, COS-H: 20 mg/kg) were administered to mice by intragastric treatment. The results showed irregular and rapid heart rates in Ang II-treated mice. Moreover, the levels of inflammatory cytokines and fibrotic factors were elevated in mice. COS triggered a reduction of Ang II-induced inflammation and fibrosis, which conferred a protective effect. Mechanistically, mitochondrial dysfunction with mitochondrial respiration inhibition and aberrant ATP levels were observed after Ang II treatment. Moreover, Ang-II-induced excessive reactive oxygen species caused oxidative stress, which was further aggravated by inhibiting Nrf2 nuclear translocation. Importantly, COS diminished these Ang-II-mediated effects in mice. In conclusion, COS attenuated inflammation and fibrosis in Ang-II-treated mice by alleviating mitochondrial dysfunction and oxidative stress. Our findings represent a potential therapeutic option for AF treatment.
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页数:10
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共 58 条
  • [1] Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
    Ahmad, F.
    Dixit, D.
    Sharma, V.
    Kumar, A.
    Joshi, S. D.
    Sarkar, C.
    Sen, E.
    [J]. CELL DEATH & DISEASE, 2016, 7 : e2213 - e2213
  • [2] Baman Jayson R, 2021, JAMA, V325, P2218, DOI 10.1001/jama.2020.23700
  • [3] Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload
    Chen, Chen
    Zou, Lei-Xin
    Lin, Qiu-Yue
    Yan, Xiao
    Bi, Hai-Lian
    Xie, Xin
    Wang, Shuai
    Wang, Qing-Shan
    Zhang, Yun-Long
    Li, Hui-Hua
    [J]. REDOX BIOLOGY, 2019, 20 : 390 - 401
  • [4] TGFβ1 and HGF regulate CTGF expression in human atrial fibroblasts and are involved in atrial remodelling in patients with rheumatic heart disease
    Chen, Jian-Quan
    Guo, Van-Song
    Chen, Qian
    Cheng, Xian-Lu
    Xiang, Guo-Jian
    Chen, Mei-Yan
    Wu, Hong-Lin
    Huang, Qi-Lei
    Zhu, Peng-Li
    Zhang, Jian-Cheng
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 23 (04) : 3032 - 3039
  • [5] Protective Effects of Costunolide against Hydrogen Peroxide-Induced Injury in PC12 Cells
    Cheong, Chong-Un
    Yeh, Ching-Sheng
    Hsieh, Yi-Wen
    Lee, Ying-Ray
    Lin, Mei-Ying
    Chen, Chung-Yi
    Lee, Chien-Hsing
    [J]. MOLECULES, 2016, 21 (07)
  • [6] PGC-1α Suppresses the Activation of TGF-β/Smad Signaling via Targeting TGFβRI Downregulation by let-7b/c Upregulation
    Choi, Hoon-In
    Park, Jung Sun
    Kim, Dong-Hyun
    Kim, Chang Seong
    Bae, Eun Hui
    Ma, Seong Kwon
    Kim, Soo Wan
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (20)
  • [7] β3-Adrenoceptor Impairs Mitochondrial Biogenesis and Energy Metabolism During Rapid Atrial Pacing-Induced Atrial Fibrillation
    Dong, Jingmei
    Zhao, Jingjing
    Zhang, Miaomiao
    Liu, Guangzhong
    Wang, Xiaobing
    Liu, Yixi
    Yang, Ning
    Liu, Yongwu
    Zhao, Guanqi
    Sun, Jiayu
    Tian, Jingpu
    Cheng, Cheping
    Wei, Lin
    Li, Yue
    Li, Weimin
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2016, 21 (01) : 114 - 126
  • [8] Angiotensin receptor-neprilysin inhibitor therapy and recurrence of atrial fibrillation after radiofrequency catheter ablation: A propensity-matched cohort study
    Dong, Youzheng
    Xiao, Shucai
    He, Jinwu
    Shi, Kaixin
    Chen, Si
    Liu, Deping
    Huang, Bin
    Zhai, Zhenyu
    Li, Juxiang
    [J]. FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
  • [9] TRPM7-Mediated Ca2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation
    Du, Jianyang
    Xie, Jia
    Zhang, Zheng
    Tsujikawa, Hiroto
    Fusco, Daniel
    Silverman, David
    Liang, Bruce
    Yue, Lixia
    [J]. CIRCULATION RESEARCH, 2010, 106 (05) : 992 - 1003
  • [10] Antioxidant activity of costunolide and eremanthin isolated from Costus speciosus (Koen ex. Retz) Sm.
    Eliza, J.
    Daisy, P.
    Ignacimuthu, S.
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2010, 188 (03) : 467 - 472