Advances of Wnt Signalling Pathway in Colorectal Cancer

被引：45
作者：
Zhu, Yaoyao [1 ]
Li, Xia [1 ,2 ]
机构：
[1] Shandong Univ, Marine Coll, Weihai 264200, Peoples R China
[2] Shandong Kelun Pharmaceut Co Ltd, Binzhou 256600, Peoples R China
来源：
CELLS | 2023年 / 12卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Wnt signalling pathway; colorectal cancer; invasion and metastasis; colitis-associated carcinoma; cancer stem cells; INFLAMMATORY-BOWEL-DISEASE; EPITHELIAL-MESENCHYMAL TRANSITION; PLANAR CELL POLARITY; STEM-CELLS; BETA-CATENIN; COLON-CANCER; PROMOTES PROLIFERATION; VANGL2; PHOSPHORYLATION; THERAPY RESISTANCE; CIRCADIAN CLOCK;
D O I：
10.3390/cells12030447
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Colorectal cancer (CRC) represents one of the most common cancers worldwide, with a high mortality rate despite the decreasing incidence and new diagnostic and therapeutic strategies. CRC arises from both epidemiologic and molecular backgrounds. In addition to hereditary factor and genetic mutations, the strongly varying incidence of CRC is closely linked to chronic inflammatory disorders of the intestine and terrible dietary habits. The Wnt signalling pathway is a complex regulatory network that is implicated in many CRC physiological processes, including cancer occurrence, development, prognosis, invasion, and metastasis. It is currently believed to include classical Wnt/beta-catenin, Wnt/PCP, and Wnt/Ca2+. In this review, we summarise the recent mechanisms and potential regulators of the three branches of the Wnt signalling pathway in CRC.
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页数：22
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