Systemic Light Chain Amyloidosis, Version 2.2023

被引：433

作者：

Kumar, Shaji K. ^{[1
]}

Callander, Natalie S. ^{[2
]}

Adekola, Kehinde ^{[3
]}

Anderson, Larry D., Jr. ^{[4
]}

Baljevic, Muhamed ^{[5
]}

Campagnaro, Erica ^{[6
]}

Castillo, Jorge J. ^{[7
,8
,9
]}

Costello, Caitlin ^{[10
]}

D'Angelo, Christopher ^{[11
]}

Devarakonda, Srinivas ^{[12
,13
]}

Elsedawy, Noura ^{[14
,15
]}

Garfall, Alfred ^{[16
]}

Godby, Kelly ^{[17
]}

Hillengass, Jens ^{[18
]}

Holmberg, Leona ^{[19
,20
]}

Htut, Myo ^{[21
]}

Huff, Carol Ann ^{[22
]}

Hultcrantz, Malin ^{[23
]}

Kang, Yubin ^{[24
]}

Larson, Sarah ^{[25
]}

Lee, Hans C. ^{[26
]}

Liedtke, Michaela ^{[27
]}

Martin, Thomas ^{[28
]}

Omel, James

Rosenberg, Aaron ^{[29
]}

Sborov, Douglas ^{[30
]}

Valent, Jason ^{[31
,32
,33
]}

Berardi, Ryan ^{[34
]}

Kumar, Rashmi ^{[34
]}

机构：

[1] Mayo Clin, Ctr Canc, Rochester, MN 55905 USA

[2] Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53706 USA

[3] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Evanston, IL 60208 USA

[4] UT Southwestern Simmons Comprehens Canc Ctr, Dallas, TX USA

[5] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[6] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[7] Dana Farber, Boston, MA USA

[8] Brighamand & Womens Canc Ctr, Boston, MA USA

[9] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA

[10] UC San Diego Moores Canc Ctr, San Diego, CA USA

[11] Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[12] Ohio State Univ, Ctr Comprehens Canc, James Canc Hosp, Columbus, OH 43210 USA

[13] Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA

[14] St Jude Childrens Res Hosp, Memphis, TN USA

[15] Univ Tennessee, Hlth Sci Ctr, Memphis, TN USA

[16] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[17] ONeal Comprehens Canc Ctr UAB, Birmingham, AL USA

[18] Roswell Pk Comprehens Canc Ctr, Buffalo, NY USA

[19] Fred Hutchinson Canc Res Ctr, Seattle, WA USA

[20] Seattle Canc Care Alliance, Seattle, WA USA

[21] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[22] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA

[23] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[24] Duke Canc Inst, Durham, NC USA

[25] UCLA Jonsson Comprehens Canc Ctr, Los Angeles, CA USA

[26] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[27] Stanford Canc Inst, Stanford, CA USA

[28] UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[29] UC Davis Comprehens Canc Ctr, Davis, CA USA

[30] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[31] Case Comprehens Canc Ctr, Cleveland, OH USA

[32] Univ Hosp Seidman Canc Ctr, Cleveland, OH USA

[33] Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44106 USA

[34] Natl Comprehens Canc Network, Plymouth Meeting, PA USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2023年 / 21卷 / 01期

关键词：

STEM-CELL TRANSPLANTATION; HIGH-DOSE MELPHALAN; COMPLETE HEMATOLOGIC RESPONSE; BRAIN NATRIURETIC PEPTIDE; TWICE-WEEKLY BORTEZOMIB; AL PRIMARY AMYLOIDOSIS; FACTOR-X DEFICIENCY; PLUS DEXAMETHASONE; CARDIAC BIOMARKERS; TREATMENT OUTCOMES;

D O I：

10.6004/jnccn.2022.0001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary systemic light chain amyloidosis (SLCA) is characterized by production of light chains that get converted to amyloid fibrils with an affinity for visceral organs and causing organ dysfunction. The therapy for SLCA is directed to recovering the function of the affected organs by targeting the abnormal plasma cell clone and slowing deposition of amyloid fibrils. The NCCN Guidelines for SLCA provide recommendations for workup, diagnosis, and treatment of primary as well as previously treated SLCA.

引用

页码：67 / 81

页数：15

共 87 条

[1] Outcomes of Patients with Light Chain Amyloidosis Who Had Autologous Stem Cell Transplantation with 3 or More Organs Involved [J].