Therapies for Type 1 Diabetes: Is a Cure Possible?

被引：4
作者：
Chuzho, Neihenuo [1 ,2 ]
Mishra, Neetu [2 ]
Tandon, Nikhil [3 ]
Kumar, Neeraj [1 ]
机构：
[1] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi, India
[2] Symbiosis Int Univ, Symbiosis Sch Biol Sci, Pune, India
[3] All India Inst Med Sci, Dept Endocrinol & Metab, New Delhi, India
来源：
CURRENT DIABETES REVIEWS | 2023年 / 19卷 / 07期
关键词：
Type; 1; diabetes; ss-cell; curative therapy; insulin; islet transplantation; encapsulation; stem cells; immunotherapy; artificial pancreas; alternative therapy; B-LYMPHOCYTE DEPLETION; BETA-CELL FUNCTION; RECENT-ONSET; ISLET XENOTRANSPLANTATION; ARTIFICIAL PANCREAS; GENE POLYMORPHISMS; T-CELLS; TRIAL; SUSCEPTIBILITY; MELLITUS;
D O I：
10.2174/1573399819666221202161259
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The current standard method for type 1 diabetes (T1D) management majorly focuses on controlling blood glucose levels with exogeneous insulin administration. Recent developments have focused on finding ways to predict and prevent the development of T1D, as well as finding a curative therapy for T1D. Such developments include ss-cell replacement therapy by islet transplantation, non-insulin adjunct therapy, gene and stem cell-based therapies, immunotherapy, and automated treatment with an artificial pancreas. In recent years, non-traditional alternative therapy has also become a popular treatment option for T1D. This review discusses the various therapeutic options for T1D currently under various stages of development, the challenges associated with the present strategies, and their potential to eventually change the way T1D is treated.
引用
收藏
页数：9
相关论文
共 85 条
[31]   Glucagon-like peptide 1 receptor agonists in type 1 diabetes mellitus [J].
Guyton, Justinne ;
Jeon, Michelle ;
Brooks, Amie .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2019, 76 (21) :1739-1748
[32]   A Novel Dual-Hormone Insulin-and-Pramlintide Artificial Pancreas for Type 1 Diabetes: A Randomized Controlled Crossover Trial [J].
Haidar, Ahmad ;
Tsoukas, Michael A. ;
Bernier-Twardy, Sarah ;
Yale, Jean-Francois ;
Rutkowski, Joanna ;
Bossy, Anne ;
Pytka, Evelyne ;
El Fathi, Anas ;
Strauss, Natalia ;
Legault, Laurent .
DIABETES CARE, 2020, 43 (03) :597-606
[33]   Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes [J].
Hannelius, Ulf ;
Beam, Craig A. ;
Ludvigsson, Johnny .
DIABETOLOGIA, 2020, 63 (10) :2177-2181
[34]   Adjunctive therapy for glucose control in patients with type 1 diabetes [J].
Harris, Kira ;
Boland, Cassie ;
Meade, Lisa ;
Battise, Dawn .
DIABETES METABOLIC SYNDROME AND OBESITY, 2018, 11 :159-173
[35]   Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial Metabolic and Immunologic Features at Baseline Identify a Subgroup of Responders [J].
Herold, Kevan C. ;
Gitelman, Stephen E. ;
Ehlers, Mario R. ;
Gottlieb, Peter A. ;
Greenbaum, Carla J. ;
Hagopian, William ;
Boyle, Karen D. ;
Keyes-Elstein, Lynette ;
Aggarwal, Sudeepta ;
Phippard, Deborah ;
Sayre, Peter H. ;
McNamara, James ;
Bluestone, Jeffrey A. .
DIABETES, 2013, 62 (11) :3766-3774
[36]   Factors influencing attitudes toward xenotransplantation clinical trials: A report of focus group studies [J].
Hurst, Daniel J. ;
Padilla, Luz A. ;
Cooper, David K. C. ;
Paris, Wayne .
XENOTRANSPLANTATION, 2021, 28 (04)
[37]   Vitamin E, Its Beneficial Role in Diabetes Mellitus (DM) and Its Complications [J].
Jain, Anand Baburao ;
Jain, Vaishali Anand .
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2012, 6 (10) :1624-1628
[38]   EFFECT OF MOMORDICA-CHARANTIA FRUIT JUICE ON STREPTOZOTOCIN-INDUCED DIABETES IN RATS [J].
KARUNANAYAKE, EH ;
JEEVATHAYAPARAN, S ;
TENNEKOON, KH .
JOURNAL OF ETHNOPHARMACOLOGY, 1990, 30 (02) :199-204
[39]   CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus:: A HuGE review and meta-analysis [J].
Kavvoura, FK ;
Ioannidis, JPA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2005, 162 (01) :3-16
[40]   What does it take to consent to islet cell xenotransplantation?: Insights from an interview study with type 1 diabetes patients and review of the literature [J].
Koegel, Johannes ;
Thiersch, Sandra ;
Ludwig, Barbara ;
Seissler, Jochen ;
Marckmann, Georg .
BMC MEDICAL ETHICS, 2021, 22 (01)
123456789