Therapies for Type 1 Diabetes: Is a Cure Possible?

被引：4
作者：
Chuzho, Neihenuo [1 ,2 ]
Mishra, Neetu [2 ]
Tandon, Nikhil [3 ]
Kumar, Neeraj [1 ]
机构：
[1] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi, India
[2] Symbiosis Int Univ, Symbiosis Sch Biol Sci, Pune, India
[3] All India Inst Med Sci, Dept Endocrinol & Metab, New Delhi, India
来源：
CURRENT DIABETES REVIEWS | 2023年 / 19卷 / 07期
关键词：
Type; 1; diabetes; ss-cell; curative therapy; insulin; islet transplantation; encapsulation; stem cells; immunotherapy; artificial pancreas; alternative therapy; B-LYMPHOCYTE DEPLETION; BETA-CELL FUNCTION; RECENT-ONSET; ISLET XENOTRANSPLANTATION; ARTIFICIAL PANCREAS; GENE POLYMORPHISMS; T-CELLS; TRIAL; SUSCEPTIBILITY; MELLITUS;
D O I：
10.2174/1573399819666221202161259
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The current standard method for type 1 diabetes (T1D) management majorly focuses on controlling blood glucose levels with exogeneous insulin administration. Recent developments have focused on finding ways to predict and prevent the development of T1D, as well as finding a curative therapy for T1D. Such developments include ss-cell replacement therapy by islet transplantation, non-insulin adjunct therapy, gene and stem cell-based therapies, immunotherapy, and automated treatment with an artificial pancreas. In recent years, non-traditional alternative therapy has also become a popular treatment option for T1D. This review discusses the various therapeutic options for T1D currently under various stages of development, the challenges associated with the present strategies, and their potential to eventually change the way T1D is treated.
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页数：9
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