Hepatitis B Virus (HBV) Replication During Tenofovir Therapy Is Frequent in Human Immunodeficiency Virus/HBV Coinfection

被引：9

作者：

Hofmann, Eveline ^{[1
]}

Surial, Bernard ^{[1
]}

Boillat-Blanco, Noemie ^{[2
,3
]}

Guenthard, Huldrych F. ^{[4
,5
]}

Stoeckle, Marcel ^{[6
]}

Bernasconi, Enos ^{[7
]}

Schmid, Patrick ^{[8
]}

Calmy, Alexandra ^{[9
]}

Suter-Riniker, Franziska ^{[10
]}

Rauch, Andri ^{[1
]}

Wandeler, Gilles ^{[1
,11
]}

Beguelin, Charles ^{[1
]}

机构：

[1] Univ Bern, Bern Univ Hosp, Dept Infect Dis, Inselspital, Bern, Switzerland

[2] Lausanne Univ Hosp, Serv Infect Dis, Lausanne, Switzerland

[3] Univ Lausanne, Lausanne, Switzerland

[4] Univ Hosp Zurich, Dept Infect Dis & Hosp Epidemiol, Zurich, Switzerland

[5] Univ Zurich, Inst Med Virol, Zurich, Switzerland

[6] Univ Basel, Univ Hosp Basel, Dept Infect Dis & Hosp Epidemiol, Basel, Switzerland

[7] Reg Hosp Lugano, Div Infect Dis, Lugano, Switzerland

[8] Cantonal Hosp St Gallen, Div Infect Dis, St Gallen, Switzerland

[9] Univ Geneva, Geneva Univ Hosp, Div Infect Dis, Geneva, Switzerland

[10] Univ Bern, Inst Infect Dis, Bern, Switzerland

[11] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

coinfection; hepatitis B virus; human immunodeficiency virus; tenofovir; viral replication; HIV;

D O I：

10.1093/cid/ciac823

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the Swiss HIV Cohort Study, 61 of 222 (27%) HIV-suppressed persons with chronic hepatitis B virus (HBV) infection had HBV replication after 2 years on tenofovir, of whom 77% were suppressed thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were predictors of persistent replication.

引用

收藏

页码：730 / 733

页数：4

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