A new depsidone from the neotricone-rich chemotype of the lichenised fungus Usnea fulvoreagens

被引：1

作者：

Burt, Scott R. ^{[1
]}

Harper, James K. ^{[1
]}

Cool, Laurence G. ^{[2
]}

机构：

[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

[2] ARS, USDA, Albany, CA 94710 USA

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 13期

基金：

美国国家科学基金会;

关键词：

chemotype; conneotricone; lichen; LC-MS; NMR; perisalazinic acid; GENUS USNEA; ACID;

D O I：

10.1080/14786419.2022.2038594

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Individuals of Usnea fulvoreagens (Parmeliaceae, lichenised Ascomycota), a shrubby corticolous species that is widespread in Europe, East Asia and North America, produce medullary lichen acids in several distinct chemotypic patterns. One such chemotype reportedly contains an unidentified substance as the major secondary metabolite. We isolated this compound from Californian specimens of U. fulvoreagens and identified it as the rare depsidone neotricone. A co-occurring compound, conneotricone, was identified as 4,10-dihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-1,3-dihydro-7H-isobenzofuro[4,5-b][1,4]benzodioxepine-11-carboxylic acid by NMR and HPLC-UV-MSn comparison with the material synthesised from salazinic acid.

引用

页码：2248 / 2254

页数：7

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