Current Insights and Future Directions in the Treatment of Heart Failure with Preserved Ejection Fraction

被引:3
作者
Chiorescu, Roxana Mihaela [1 ,2 ]
Lazar, Roxana-Daiana [3 ]
Ruda, Alexandru [3 ]
Buda, Andreea Paula [3 ]
Chiorescu, Stefan [4 ]
Mocan, Mihaela [1 ,2 ]
Blendea, Dan [3 ,5 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med, Cluj Napoca 400012, Romania
[2] Emergency Clin Cty Hosp, Dept Internal Med, Cluj Napoca 400006, Romania
[3] Nicolae Stancioiu Heart Inst, Cluj Napoca 400001, Romania
[4] Iuliu Hatieganu Univ Med & Pharm, Dept Surg, Cluj Napoca 400139, Romania
[5] Iuliu Hatieganu Univ Med & Pharm, Dept Cardiol, Cluj Napoca 400437, Romania
关键词
heart failure; ejection fraction; microARN; serpina; melatonina; CORONARY MICROVASCULAR DYSFUNCTION; EPICARDIAL ADIPOSE-TISSUE; OXIDATIVE STRESS; MELATONIN; INJURY; PATHOPHYSIOLOGY; TARGET; RATS;
D O I
10.3390/ijms25010440
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Heart failure is a clinical syndrome associated with poor quality of life, substantial healthcare resource utilization, and premature mortality, in large part related to high rates of hospitalizations. The clinical manifestations of heart failure are similar regardless of the ejection fraction. Unlike heart failure with reduced ejection fraction, there are few therapeutic options for treating heart failure with preserved ejection fraction. Molecular therapies that have shown reduced mortality and morbidity in heart failure with reduced ejection have not been proven to be effective for patients with heart failure and preserved ejection fraction. The study of pathophysiological processes involved in the production of heart failure with preserved ejection fraction is the basis for identifying new therapeutic means. In this narrative review, we intend to synthesize the existing therapeutic means, but also those under research (metabolic and microRNA therapy) for the treatment of heart failure with preserved ejection fraction.
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页数:21
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