Pharmacological Progresses of Puerarin in the Prevention and Treatment of Atherosclerosis

被引：0

作者：

Jia, Liyi ^{[1
]}

Xing, Lu. ^{[2
]}

Li, Pengquan ^{[2
]}

Chu, Haiqing ^{[2
]}

Zhou, Xin ^{[2
]}

Qin, Wei ^{[2
]}

He, Chunxia ^{[2
]}

Li, Huijin ^{[2
]}

Zhao, Dong ^{[2
]}

Zhang, Juan ^{[1
]}

Cao, Huiling ^{[2
]}

机构：

[1] Shaanxi Univ Chinese Med, Coll Pharm, Xianyang 712046, Shaanxi, Peoples R China

[2] Xian Med Univ, Coll Pharm, Xian Key Lab Basic & Translat Cardiovasc Metab Dis, Xian 710021, Shaanxi, Peoples R China

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2023年 / 85卷 / 04期

基金：

芬兰科学院;

关键词：

Puerarin; atherosclerosis; hyperglycemic; anti-inflammatory; pharmacological activity; RADIX-PUERARIAE; HYPERGLYCEMIA; OPTIMIZATION; DAIDZEIN; PATHWAY;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atherosclerosis is an independent risk factor for cardiovascular diseases, which is related to dyslipidemia, endothelial injury, inflammation, thrombosis, dysfunction of vascular smooth muscle cells and macrophages, etc. Puerarin, a natural monomer from Chinese herb Pueraria lobata, presents multiple cardiovascular protective activities. The paper firstly reviewed the risk factors and drug of atherosclerosis. And then, extraction and synthesis of puerarin were summarized. Especially, it focused on the latest advances in anti-atherosclerosis activities of puerarin from six aspects including lipid-regulating, hyperglycemic, antiinflammatory, inhibiting thrombosis, promoting microcirculation, improving functions of vascular smooth muscle cells and macrophages. Some novel puerarin derivatives also exhibited favorable anti-atherosclerosis activity. The review would provide new molecular skeletons and lead compounds for anti-atherosclerosis new drug development based on puerarin.

引用

页码：884 / 894

页数：11

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