Relationship between critical care nutrition and post-intensive care syndrome in surviving ventilated patients with COVID-19: a multicenter prospective observational study

被引：3

作者：

Nakamura, Kensuke ^{[1
,2
]}

Hatakeyama, Junji ^{[3
]}

Liu, Keibun ^{[4
,5
,6
]}

Yamakawa, Kazuma ^{[3
]}

Nishida, Takeshi ^{[7
]}

Ohshimo, Shinichiro ^{[8
]}

Inoue, Shigeaki ^{[9
]}

Hashimoto, Satoru ^{[6
]}

Maruyama, Shuhei ^{[10
]}

Kawakami, Daisuke ^{[11
]}

Ogata, Yoshitaka ^{[12
]}

Hayakawa, Katsura ^{[13
]}

Shimizu, Hiroaki ^{[14
]}

Oshima, Taku ^{[15
,16
]}

Fuchigami, Tatsuya ^{[17
]}

Nishida, Osamu ^{[18
]}

机构：

[1] Yokohama City Univ Med, Dept Crit Care Med, 3-9 Fukuura,Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Hitachi Gen Hosp, Dept Emergency & Crit Care Med, 2-1-1 Jonan Cho, Hitachi, Ibaraki 3170077, Japan

[3] Osaka Med & Pharmaceut Univ, Dept Emergency & Crit Care Med, 2-7 Daigaku Machi, Takatsuki, Osaka 5698686, Japan

[4] Prince Charles Hosp, Crit Care Res Grp, 627 Rode Rd, Chermside, Qld 4032, Australia

[5] Univ Queensland, Inst Mol Biosci IMB, 306 Carmody Rd, St Lucia, Qld 4067, Australia

[6] ICU Collaborat Network ICON, 2-15-13-10F Hongo,Bunkyo Ku, Tokyo 1130033, Japan

[7] Osaka Gen Med Ctr, Div Trauma & Surg Crit Care, 3-1-56 Bandai Higashi,Sumiyoshi Ku, Osaka 5588558, Japan

[8] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Emergency & Crit Care Med, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348551, Japan

[9] Wakayama Med Univ, Dept Emergency & Crit Care Med, 811-1 Kimiidera, Wakayama 6418509, Japan

[10] Kansai Med Univ, Dept Emergency & Crit Care Med, Med Ctr, 10-15 Fumizono Cho,Asahi Ku, Osaka 5708507, Japan

[11] Kobe City Med Ctr Gen Hosp, Dept Anesthesia & Crit Care, 2-1-1 Minatojimaminami Machi,Chuo Ku, Kobe, Hyogo 6500047, Japan

[12] Yao Tokushukai Gen Hosp, Dept Crit Care Med, 1-17 Wakakusa Cho, Yao, Osaka 5810011, Japan

[13] Saitama Red Cross Hosp, Dept Emergency & Crit Care Med, 1-5 Shintoshin,Chuo Ku, Saitama 3308553, Japan

[14] Hyogo Prefectural Harima Himeji Gen Med Ctr, Acute Care Div, 3-264 Kamiya Cho, Himeji, Hyogo 6708560, Japan

[15] Chiba Univ, Inst Adv Acad Res, 1-33 Yayoi Cho,Inage Ku, Chiba 2638522, Japan

[16] Chiba Univ, Dept Emergency & Crit Care Med, Grad Sch Med, 1-8-1 Inohana,Chuo Ku, Chiba 2608677, Japan

[17] Univ Ryukyus Hosp, Dept Anesthesiol & Intens Care Med, 207 Uehara, Nishihara, Okinawa 9030215, Japan

[18] Fujita Hlth Univ, Dept Anesthesiol & Crit Care Med, Sch Med, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2024年 / 74卷 / 01期

关键词：

PICS; ICU-AW; COVID-19; nutrition; protein; parenteral nutrition;

D O I：

10.3164/jcbn.23-66

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The impact of nutrition therapy in the acute phase on postintensive care syndrome (PICS) remains unclear. We conducted a multicenter prospective study on adult patients with COVID-19 who required mechanical ventilation for more than three days. The questionnaire was mailed after discharge. Physical PICS, defined as less than 90 points on the Barthel index (BI), was assigned as the primary outcome. We examined the types of nutrition therapy in the first week that affected PICS components. 269 eligible patients were evaluated 10 months after discharge. Supplemental parenteral nutrition (SPN) >400 kcal/day correlated with a lower occurrence of physical PICS (10% vs 21.92%, p= 0.042), whereas the amounts of energy and protein provided, early enteral nutrition, and a gradual increase in nutrition delivery did not, and none correlated with cognitive or mental PICS. A multivariable regression analysis revealed that SPN had an independent impact on physical PICS (odds ratio 0.33, 95% CI 0.12-0.92, p = 0.034), even after adjustments for age, sex, body 0.42, 95% CI 0.16-1.08, p = 0.071). In conclusion, SPN in the acute patients with COVID-19.

引用

页码：74 / 81

页数：8

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