Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women

被引：4

作者：

Anto, Enoch Odame ^{[1
,2
]}

Boadu, Wina Ivy Ofori ^{[1
]}

Addai-Mensah, Otchere ^{[1
]}

Wiafe, Yaw Amo ^{[1
]}

Owiredu, William K. B. A. ^{[3
]}

Obirikorang, Christian ^{[3
]}

Annani-Akollor, Max Efui ^{[3
]}

Adua, Eric ^{[4
]}

Appiah, Michael ^{[5
]}

Opoku, Stephen ^{[1
]}

Acheampong, Emmanuel ^{[2
,4
]}

Asamoah, Evans Adu ^{[3
]}

Owiredu, Eddie-Williams ^{[3
]}

Anto, Agartha Odame ^{[6
]}

Tawiah, Augustine ^{[7
]}

Ankobea, Frank ^{[7
]}

Yamoah, Ebenezer Afrifa ^{[8
]}

Coall, David Antony ^{[2
]}

机构：

[1] Kwame Nkrumah Univ Sci & Technol, Fac Allied Hlth Sci, Dept Med Diagnost, Kumasi, Ghana

[2] Edith Cowan Univ, Ctr Precis Hlth, Sch Med & Hlth Sci, Perth, WA, Australia

[3] Kwame Nkrumah Univ Sci & Technol, Dept Mol Med, Kumasi, Ghana

[4] Univ New South Wales, Rural Clin Sch Med & Hlth, Wagga Wagga, NSW, Australia

[5] Accra Tech Univ, Dept Med Lab Sci, Accra, Ghana

[6] Ho Teaching Hosp, Dept Obstet & Gynaecol, Volta, Ho, Ghana

[7] Komfo Anokye Teaching Hosp, Dept Obstet & Gynaecol, Kumasi, Ghana

[8] Edith Cowan Univ, Sch Sci, Perth, WA, Australia

来源：

SAGE OPEN MEDICINE | 2023年 / 11卷

关键词：

Micronutrients; oxidative stress; angiogenic growth mediators; early-onset preeclampsia; late-onset preeclampsia; ENDOTHELIAL DYSFUNCTION; TYROSINE KINASE-1; SOLUBLE ENDOGLIN; PATHOGENESIS; CALCIUM; PREGNANCY; MAGNESIUM; BLOOD;

D O I：

10.1177/20503121231175759

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives:Micronutrients, especially calcium (Ca) and magnesium (Mg) are reported to reduce preeclampsia events via several factors such as endothelial cell control, optimal oxidative stress and a balanced angiogenic growth mediator. We evaluated the association of micronutrients with oxidative stress biomarkers, and angiogenic growth mediators in early-onset preeclampsia and late-onset preeclampsia. Methods:This case-control study recruited 197 preeclampsia (early-onset preeclampsia = 70 and late-onset preeclampsia = 127) as cases and 301 normotensive pregnant women as controls from the Komfo Anokye Teaching Hospital, Ghana. Samples were collected after 20 weeks of gestation for both cases and controls and estimated for Ca, Mg, soluble fms-like tyrosine kinase-1, placental growth factor, vascular endothelial growth factor-A, soluble endoglin, 8-hydroxydeoxyguanosine, 8-epiprostaglandinF2-alpha and total antioxidant capacity. Results:Early-onset preeclampsia women had significantly lower levels of Ca, Mg, placental growth factor, vascular endothelial growth factor-A and total antioxidant capacity but higher levels of soluble fms-like tyrosine kinase-1, soluble endoglin, 8-epiprostaglandinF2-alpha, 8-hydroxydeoxyguanosine, soluble fms-like tyrosine kinase-1/placental growth factor ratio, 8-epiprostaglandinF2-alpha /placental growth factor ratio, 8-hydroxydeoxyguanosine/placental growth factor ratio and soluble endoglin/placental growth factor ratio than late-onset preeclampsia and normotensive pregnant women (p < 0.0001). Among the early-onset preeclampsia women, the first and second quartile for serum placental growth factor, first quartile for vascular endothelial growth factor-A and total antioxidant capacity and the fourth quartiles for serum sEng, serum sFlt-1, 8-epiPGF2 alpha and 8-OHdG were independently associated with low Ca and Mg (p < 0.05). Among late-onset preeclampsia women, the fourth quartile for soluble fms-like tyrosine kinase-1 was independently associated with low Ca and Mg (p < 0.05). Conclusion:Magnesium and calcium are associated with an imbalance in angiogenic growth mediators and oxidative stress biomarkers among preeclampsia women, particularly early-onset preeclampsia. Serial and routine measurement of these micronutrients would allow the monitoring of poor placental angiogenesis while enabling an understanding of the triggers of increased oxidative stress and reduced antioxidant in preeclampsia.

引用

页数：16

共 36 条

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