The IPD-IMGT/HLA Database

被引：950
作者：
Barker, Dominic J. [1 ,2 ]
Maccari, Giuseppe [3 ]
Georgiou, Xenia [1 ]
Cooper, Michael A. [1 ]
Flicek, Paul [4 ]
Robinson, James [1 ,2 ]
Marsh, Steven G. E. [1 ,2 ]
机构：
[1] Anthony Nolan Res Inst, Royal Free Hosp, Pond St, London NW3 2QG, England
[2] Univ Coll London UCL, UCL Canc Inst, Royal Free Campus,Pond St, London NW3 2QG, England
[3] Fdn Toscana Life Sci, Data Sci Hlth DaScH Lab, Siena, Italy
[4] European Mol Biol Lab, European Bioinformat Inst EMBL EBI, Wellcome Genome Campus, Cambridge CB10 1SD, England
来源：
NUCLEIC ACIDS RESEARCH | 2023年 / 51卷 / D1期
关键词：
HEMATOPOIETIC-CELL TRANSPLANTATION; HLA SYSTEM; SEQUENCE DATABASE; NOMENCLATURE; HLA-DPB1; MISMATCHES; ALLOREACTIVITY; RECIPIENTS; ALLELES; IMPACT;
D O I：
10.1093/nar/gkac1011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is 24 years since the IPD-IMGT/HLA Database, http: //www.ebi.ac.uk/ ipd/imgt/hla/, was first released, providing the HLA community with a searchable repository of highly curated HLA sequences. The database now contains over 35 000 alleles of the human Major Histocompatibility Complex (MHC) named by the WHO Nomenclature Committee for Factors of the HLA System. This complex contains the most polymorphic genes in the human genome and is now considered hyperpolymorphic. The IPD-IMGT/HLA Database provides a stable and user-friendly repository for this information. Uptake of Next Generation Sequencing technology in recent years has driven an increase in the number of alleles and the length of sequences submitted. As the size of the database has grown the traditional methods of accessing and presenting this data have been challenged, in response, we have developed a suite of tools providing an enhanced user experience to our traditional web-based users while creating new programmatic access for our bioinformatics user base. This suite of tools is powered by the IPD-API, an Application Programming Interface (API), providing scalable and flexible access to the database. The IPD-API provides a stable platform for our future development allowing us to meet the future challenges of the HLA field and needs of the community.
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收藏
页码：D1053 / D1060
页数：8
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