New polyketides from the starfish-derived symbiotic fungus Penicillium sp. GGF16-1-2

被引：1

作者：

He, Yu-Pei ^{[1
]}

Xiang, Jun ^{[2
]}

Shao, Xue-Hua ^{[3
]}

Feng, Chan ^{[1
]}

Zhang, Qi ^{[1
]}

Wang, Yu-Mei ^{[1
]}

Zhang, Cui-Xian ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Pharm, Guangzhou 510120, Peoples R China

[3] Minist Agr & Rural Affairs, Guangdong Prov Key Lab Trop & Subtrop Fruit Tree R, Key Lab South Subtrop Fruit Biol & Genet Resource, Guangzhou 510640, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2024年

基金：

中国国家自然科学基金;

关键词：

Penicillium sp; citrinin derivatives; antifungal activities; CITRININ DIMERS;

D O I：

10.1080/10286020.2024.2311140

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One new rare carbon-bridged citrinin dimer quinocitrindimer C (1) as a pair of epimers, two new polyketide penicilliodes D (3) and E (4) together with nine known citrinin derivatives, were isolated from the fermentation broth of starfish-derived symbiotic fungus Penicillium sp. GGF16-1-2. Their structures and configurations were elucidated by comprehensively spectroscopic data analysis and electronic circular dichroism calculations. Eleven citrinin derivatives were tested by Colletotrichum gloeosporioides, and compound 2 played a significant antifungal activity against Colletotrichum gloeosporioides with LC50 value of 0.27 mu g/ml.

引用

页数：10

共 24 条

[1] New citrinin derivatives from the deep-sea-derived fungus Cladosporium sp. SCSIO z015 [J].

Amin, Muhammad ;

Zhang, Xiao-Yong ;

Xu, Xin-Ya ;

Qi, Shu-Hua .

NATURAL PRODUCT RESEARCH, 2020, 34 (09) :1219-1226

[2]

Bruhn T., 2017, SpecDis, Version 1.71

[3]

Dame ZT, 2015, NAT PROD COMMUN, V10, P623

[4] Unprecedented Citrinin Trimer Tricitinol B Functions as a Novel Topoisomerase IIα Inhibitor [J].

Du, Lin ;

Liu, Hong-Chun ;

Fu, Wei ;

Li, De-Hai ;

Pan, Qiu-Ming ;

Zhu, Tian-Jiao ;

Geng, Mei-Yu ;

Gu, Qan-Qun .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (16) :5796-5810

[5] Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities [J].

Du, Lin ;

Li, Dehai ;

Zhang, Guojian ;

Zhu, Tianjiao ;

Ai, Jing ;

Gu, Qianqun .

TETRAHEDRON, 2010, 66 (47) :9286-9290

[6] Rare Carbon-Bridged Citrinin Dimers from the Starfish-Derived Symbiotic Fungus Penicillium sp. GGF16-1-2 [J].

Fan, Hao ;

Shi, Zhi-Mian ;

Lei, Yan-Hu ;

Si-Tu, Mei-Xia ;

Zhou, Feng-Guo ;

Feng, Chan ;

Wei, Xia ;

Shao, Xue-Hua ;

Chen, Yang ;

Zhang, Cui-Xian .

MARINE DRUGS, 2022, 20 (07)

[7] Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis [J].

Fan, Yaqin ;

Shen, Jingjing ;

Liu, Zhi ;

Xia, Kunyu ;

Zhu, Weiming ;

Fu, Peng .

NATURAL PRODUCT REPORTS, 2022, 39 (06) :1305-1324

[8]

[冯婵 Feng Chan], 2020, [中国海洋药物, Chinese Journal of Marine Drugs], V39, P23

[9]

Frisch M.J., Gaussian 09, Revision D.01

[10] A NEW CYTOTOXIC ISOCOUMARIN FROM ENDOPHYTIC FUNGUS Penicillium SP 091402 OF THE MANGROVE PLANT Bruguiera sexangula [J].

Han, Zhuang ;

Mei, Wenli ;

Zhao, Youxing ;

Deng, Yuanyuan ;

Dai, Haofu .

CHEMISTRY OF NATURAL COMPOUNDS, 2009, 45 (06) :805-807

← 1 2 3 →