Iron-Catalyzed Direct C3-H Trifluoromethylthiolation of Quinoxalin-2(1H)-ones

被引：7

作者：

Chen, Xiaoyu ^{[1
]}

Geng, Yang ^{[2
]}

Zhu, Yu ^{[1
]}

Zou, Dapeng ^{[1
]}

Wu, Yangjie ^{[1
]}

Wu, Yusheng ^{[1
,3
,4
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Railway Vocat & Tech Coll, Dept Pharm, Zhengzhou 451460, Peoples R China

[3] TYK Med Inc, Huzhou 313000, Peoples R China

[4] Tetranov Int Inc, 100 Jersey Ave,Suite A340, New Brunswick, NJ 08901 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Fe-catalyzed; Trifluoromethylthiolation; Radicals; Quinoxalin-2(1H)-ones; C-H functionalization; OXIDATIVE TRIFLUOROMETHYLTHIOLATION; SILVER(I) TRIFLUOROMETHANETHIOLATE; SUBSTITUENT CONSTANTS; CYCLIZATION; SULFIDES; ACIDS; PHOSPHONATION; DERIVATIVES; ALKYLATION; ARYLATION;

D O I：

10.1002/adsc.202301138

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An iron-catalyzed direct C3-H radical trifluoromethylthiolation of quinoxalin-2(1H)-ones has been developed. This protocol uses earth-abundant FeSO4 & sdot; 7H(2)O as the catalyst, and AgSCF3 as the trifluoromethylthiolating reagent to provide various SCF3-containing quinoxalin-2(1H)-one derivatives in 26-88% yields. Preliminary mechanistic investigations indicate that the reaction proceeds through a radical pathway.

引用

页码：214 / 219

页数：6

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