Iron-Catalyzed Direct C3-H Trifluoromethylthiolation of Quinoxalin-2(1H)-ones

被引：5
|
作者：
Chen, Xiaoyu [1 ]
Geng, Yang [2 ]
Zhu, Yu [1 ]
Zou, Dapeng [1 ]
Wu, Yangjie [1 ]
Wu, Yusheng [1 ,3 ,4 ]
机构：
[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Railway Vocat & Tech Coll, Dept Pharm, Zhengzhou 451460, Peoples R China
[3] TYK Med Inc, Huzhou 313000, Peoples R China
[4] Tetranov Int Inc, 100 Jersey Ave,Suite A340, New Brunswick, NJ 08901 USA
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Fe-catalyzed; Trifluoromethylthiolation; Radicals; Quinoxalin-2(1H)-ones; C-H functionalization; OXIDATIVE TRIFLUOROMETHYLTHIOLATION; SILVER(I) TRIFLUOROMETHANETHIOLATE; SUBSTITUENT CONSTANTS; CYCLIZATION; SULFIDES; ACIDS; PHOSPHONATION; DERIVATIVES; ALKYLATION; ARYLATION;
D O I：
10.1002/adsc.202301138
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An iron-catalyzed direct C3-H radical trifluoromethylthiolation of quinoxalin-2(1H)-ones has been developed. This protocol uses earth-abundant FeSO4 & sdot; 7H(2)O as the catalyst, and AgSCF3 as the trifluoromethylthiolating reagent to provide various SCF3-containing quinoxalin-2(1H)-one derivatives in 26-88% yields. Preliminary mechanistic investigations indicate that the reaction proceeds through a radical pathway.
引用
收藏
页码：214 / 219
页数：6
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