The signaling pathways and targets of natural products from traditional Chinese medicine treating gastric cancer provide new candidate therapeutic strategies

被引:24
作者
Liao, Yile [1 ]
Gui, Yu [2 ,3 ]
Li, Qingzhou [4 ]
An, Jun [1 ]
Wang, Dong [1 ]
机构
[1] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, State Key Lab Southwestern Chinese Med Resources, 1166 Liutai Ave, Chengdu 611137, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Clin Res Ctr Breast, Lab Integrat Med,State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
[3] Collaborat Innovat Ctr, Chengdu 610041, Sichuan, Peoples R China
[4] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2023年 / 1878卷 / 06期
基金
中国国家自然科学基金;
关键词
Gastric cancer; Traditional Chinese Medicine; Natural products; Signaling pathways; Molecular mechanisms; NF-KAPPA-B; CELL-CYCLE ARREST; ACID INDUCES APOPTOSIS; IN-VITRO; DRUG-RESISTANCE; DOWN-REGULATION; INHIBITS PROLIFERATION; ANTICANCER ACTIVITY; CARCINOMA CELLS; AGS CELLS;
D O I
10.1016/j.bbcan.2023.188998
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Gastric cancer (GC) is one of the severe malignancies with high incidence and mortality, especially in Eastern Asian countries. Significant advancements have been made in diagnosing and treating GC over the past few decades, resulting in tremendous improvements in patient survival. In recent years, traditional Chinese medicine (TCM) has garnered considerable attention as an alternative therapeutic approach for GC due to its multicomponent and multitarget characteristics. Consequently, natural products found in TCM have attracted researchers' attention, as growing evidence suggests that these natural products can impede GC progression by regulating various biological processes. Nevertheless, their molecular mechanisms are not systematically uncovered. Here, we review the major signaling pathways involved in GC development. Additionally, clinical GC samples were analyzed. Moreover, the anti-GC effects of natural products, their underlying mechanisms and potential targets were summarized. These summaries are intended to facilitate further relevant research, and accelerate the clinical applications of natural products in GC treatment.
引用
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页数:19
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