Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era

被引:2
作者
Cao, Qian [1 ]
Du, Xin [1 ]
Jiang, Xiao-yan [1 ]
Tian, Yuan [1 ]
Gao, Chen-hao [1 ]
Liu, Zi-yu [1 ]
Xu, Ting [1 ]
Tao, Xing-xing [1 ]
Lei, Ming [1 ]
Wang, Xiao-qiang [1 ]
Ye, Lingyu Linda [1 ,2 ,3 ]
Duan, Dayue Darrel [1 ,2 ,3 ,4 ]
机构
[1] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Ctr Phen Tradit Chinese Med, Luzhou 646000, Peoples R China
[2] Southwest Med Univ, Inst Integrated Chinese & Western Med, Luzhou 646000, Peoples R China
[3] Peoples Hosp Ningxia Hui Autonomous Reg, Key Lab Autoimmune Dis & Precis Medicie, Yinchuan 750001, Peoples R China
[4] Univ Nevada Reno, Dept Pharmacol, Sch Med, Reno, NV 89557 USA
关键词
COVID-19; cardiovascular disease; PheWAS; precision medicine; Traditional Chinese Medicine; TRADITIONAL CHINESE MEDICINE; CLINICAL CHARACTERISTICS; SARS-COV-2; INFECTION; COVID-19; CORONAVIRUS; ACE2; DIAGNOSIS; SARS; PHARMACOLOGY; MECHANISMS;
D O I
10.1038/s41401-023-01119-1
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
SARS-CoV-2 infection causes injuries of not only the lungs but also the heart and endothelial cells in vasculature of multiple organs, and induces systemic inflammation and immune over-reactions, which makes COVID-19 a disease phenome that simultaneously affects multiple systems. Cardiovascular diseases (CVD) are intrinsic risk and causative factors for severe COVID-19 comorbidities and death. The wide-spread infection and reinfection of SARS-CoV-2 variants and the long-COVID may become a new common threat to human health and propose unprecedented impact on the risk factors, pathophysiology, and pharmacology of many diseases including CVD for a long time. COVID-19 has highlighted the urgent demand for precision medicine which needs new knowledge network to innovate disease taxonomy for more precise diagnosis, therapy, and prevention of disease. A deeper understanding of CVD in the setting of COVID-19 phenome requires a paradigm shift from the current phenotypic study that focuses on the virus or individual symptoms to phenomics of COVID-19 that addresses the inter-connectedness of clinical phenotypes, i.e., clinical phenome. Here, we summarize the CVD manifestations in the full clinical spectrum of COVID-19, and the phenome-wide association study of CVD interrelated to COVID-19. We discuss the underlying biology for CVD in the COVID-19 phenome and the concept of precision medicine with new phenomic taxonomy that addresses the overall pathophysiological responses of the body to the SARS-CoV-2 infection. We also briefly discuss the unique taxonomy of disease as Zheng-hou patterns in traditional Chinese medicine, and their potential implications in precision medicine of CVD in the post-COVID-19 era.
引用
收藏
页码:2347 / 2357
页数:11
相关论文
共 144 条
[1]   SARS-CoV-2 Complicated by a Large Hemorrhagic Pericardial Effusion [J].
Abdelsayed, Nardine ;
Mckinney, Benjamin ;
Carter, Mary .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (02)
[2]   "LONG COVID": an insight [J].
Ahmad, M. S. ;
Shaik, R. A. ;
Ahmad, R. K. ;
Yusuf, M. ;
Khan, M. ;
Almutairi, A. B. ;
Alghuyaythat, W. K. Z. ;
Almutairi, S. B. .
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2021, 25 (17) :5561-5577
[3]   "Fei Yan No. 1" as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic Study [J].
Ai, Zhongzhu ;
Zhou, Shanshan ;
Li, Weinan ;
Wang, Mengfan ;
Wang, Linqun ;
Hu, Gangming ;
Tao, Ran ;
Wang, Xiaoqin ;
Shen, Yinfeng ;
Xie, Lihan ;
Ba, Yuanming ;
Wu, Hezhen ;
Yang, YanFang .
FRONTIERS IN PHARMACOLOGY, 2020, 11
[4]   Prognostic Impact of Prior Heart Failure in Patients Hospitalized With COVID-19 [J].
Alvarez-Garcia, Jesus ;
Lee, Samuel ;
Gupta, Arjun ;
Cagliostro, Matthew ;
Joshi, Aditya A. ;
Rivas-Lasarte, Mercedes ;
Contreras, Johanna ;
Mitter, Sumeet S. ;
LaRocca, Gina ;
Tlachi, Pilar ;
Brunjes, Danielle ;
Glicksberg, Benjamin S. ;
Levin, Matthew A. ;
Nadkarni, Girish ;
Fayad, Zahi ;
Fuster, Valentin ;
Mancini, Donna ;
Lala, Anuradha .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 76 (20) :2334-2348
[5]   The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19 [J].
An, Xuedong ;
Zhang, YueHong ;
Duan, Liyun ;
Jin, De ;
Zhao, Shenghui ;
Zhou, RongRong ;
Duan, Yingying ;
Lian, Fengmei ;
Tong, Xiaolin .
BIOMEDICINE & PHARMACOTHERAPY, 2021, 137
[6]   Acute and Chronic Effects of COVID-19 on the Cardiovascular System [J].
Arevalos, Victor ;
Ortega-Paz, Luis ;
Rodriguez-Arias, Juan Jose ;
Calvo Lopez, Margarita ;
Castrillo-Golvano, Leticia ;
Salazar-Rodriguez, Anthony ;
Sabate-Tormos, Marta ;
Spione, Francesco ;
Sabate, Manel ;
Brugaletta, Salvatore .
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE, 2021, 8 (10)
[7]   Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study [J].
Ayoubkhani, Daniel ;
Khunti, Kamlesh ;
Nafilyan, Vahe ;
Maddox, Thomas ;
Humberstone, Ben ;
Diamond, Ian ;
Banerjee, Amitava .
BMJ-BRITISH MEDICAL JOURNAL, 2021, 372
[8]   Phenome-Wide Association Studies Uncover a Novel Association of Increased Atrial Fibrillation in Male Patients With Systemic Lupus Erythematosus [J].
Barnado, April ;
Carroll, Robert J. ;
Casey, Carolyn ;
Wheless, Lee ;
Denny, Joshua C. ;
Crofford, Leslie J. .
ARTHRITIS CARE & RESEARCH, 2018, 70 (11) :1630-1636
[9]   Therapeutic Uses of Traditional Chinese Medicines Against COVID-19 [J].
Buabeid, Manal ;
Ijaz, Munazza ;
Shamim, Saba ;
Huang, Xianju ;
Murtaza, Ghulam .
INFECTION AND DRUG RESISTANCE, 2021, 14 :5017-5026
[10]   Persistent Symptoms in Patients After Acute COVID-19 [J].
Carfi, Angelo ;
Bernabei, Roberto ;
Landi, Francesco .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 324 (06) :603-605