Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review

被引：183
作者：
Viegas, Claudia [1 ,2 ,3 ,4 ]
Patricio, Ana B. [3 ,4 ]
Prata, Joao M. [3 ,4 ]
Nadhman, Akhtar [5 ]
Chintamaneni, Pavan Kumar [6 ]
Fonte, Pedro [1 ,3 ,4 ,7 ]
机构：
[1] Univ Algarve, Ctr Marine Sci CCMar, Gambelas Campus, P-8005139 Faro, Portugal
[2] Univ Algarve, Fac Med & Biomed Sci FMCB, Gambelas Campus, P-8005139 Faro, Portugal
[3] Univ Lisbon, Inst Bioengn & Biosci, Dept Bioengn, Inst Super Tecn, Ave Rovisco Pais, P-1049001 Lisbon, Portugal
[4] Univ Lisbon, Inst Hlth & Bioecon, Associate Lab i4HB, Inst Super Tecn, Ave Rovisco Pais, P-1049001 Lisbon, Portugal
[5] CECOS Univ, Inst Integrat Biosci, Peshawar 25000, Pakistan
[6] GITAM, GITAM Sch Pharm, Dept Pharmaceut, Hyderabad Campus, Hyderabad 502329, Telangana, India
[7] Univ Algarve, Fac Sci & Technol, Dept Chem & Pharm, Gambelas Campus, P-8005139 Faro, Portugal
来源：
PHARMACEUTICS | 2023年 / 15卷 / 06期
关键词：
lipid nanoparticle; NLC; nanocarrier; nanoparticle characterization; nanoparticle production; SLN; DRUG-DELIVERY SYSTEMS; IN-VITRO; CELLULAR UPTAKE; GAMBOGIC ACID; NLC; SLN; CANCER; CYTOTOXICITY; NANOCARRIERS; INSULIN;
D O I：
10.3390/pharmaceutics15061593
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on.
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页数：34
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