Alteration of gut microbiome and metabolome by Clostridium butyricum can repair the intestinal dysbiosis caused antibiotics in mice

被引：7

作者：

Liu, Xin ^{[1
,2
]}

Qiu, Xiaoyu ^{[1
,3
]}

Yang, Yong ^{[3
,4
]}

Wang, Jing ^{[1
,3
]}

Wang, Qi ^{[1
]}

Liu, Jingbo ^{[4
]}

Yang, Feiyun ^{[1
,3
]}

Liu, Zuohua ^{[1
,3
]}

Qi, Renli ^{[1
,3
]}

机构：

[1] Chongqing Acad Anim Sci, Chongqing 402460, Peoples R China

[2] Southwest Univ, Coll Anim Sci & Technol, Chongqing 402460, Peoples R China

[3] Natl Pig Technol Innovat Ctr, Chongqing 402460, Peoples R China

[4] Southwest Univ Sci & Technol, Coll Life Sci, Mianyang 621000, Peoples R China

来源：

ISCIENCE | 2023年 / 26卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PERFORMANCE; MICROFLORA; EXPRESSION; STRESS; HEALTH; GROWTH; ACIDS;

D O I：

10.1016/j.isci.2023.106190

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study evaluated the repair effects of Clostridium butyricum (CBX 2021) on the antibiotic (ABX)-induced intestinal dysbiosis in mice by the multi-omics method. Results showed that ABX eliminated more than 90% of cecal bacteria and also exerted adverse effects on the intestinal structure and overall health in mice after 10 days of the treatment. Of interest, supplementing CBX 2021 in the mice for the next 10 days colonized more butyrate-producing bacteria and accelerated butyrate production compared with the mice by natural recovery. The reconstruction of intestinal microbiota efficiently promoted the improvement of the damaged gut morphology and physical barrier in the mice. In addition, CBX 2021 significantly reduced the content of disease-related metabolites and meanwhile promoted carbohydrate digestion and absorption in mice followed the microbiome alternation. In conclusion, CBX 2021 can repair the intestinal ecology of mice damaged by the antibiotics through reconstructing gut microbiota and optimizing metabolic functions.

引用

页数：20