Diabetes, brain health, and treatment gains in post-stroke aphasia

被引：5

作者：

Roth, Rebecca ^{[1
]}

Busby, Natalie ^{[2
]}

Wilmskoetter, Janina ^{[3
]}

Schwen Blackett, Deena ^{[4
]}

Gleichgerrcht, Ezequiel ^{[4
]}

Johnson, Lisa ^{[2
]}

Rorden, Chris ^{[5
]}

Newman-Norlund, Roger ^{[5
]}

Hillis, Argye E. ^{[6
]}

den Ouden, Dirk B. ^{[2
]}

Fridriksson, Julius ^{[2
]}

Bonilha, Leonardo ^{[1
,7
]}

机构：

[1] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA

[2] Univ South Carolina, Dept Commun Sci & Disorders, Columbia, SC 29208 USA

[3] Med Univ South Carolina, Dept Rehabil Sci, Charleston, SC 29425 USA

[4] Med Univ South Carolina, Dept Neurol, Charleston, SC 29425 USA

[5] Univ South Carolina, Dept Psychol, Columbia, SC 29208 USA

[6] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21218 USA

[7] Emory Univ, Brain Hlth Ctr, Dept Neurol, 12 Execut Pk Dr NE, Atlanta, GA 30329 USA

来源：

CEREBRAL CORTEX | 2023年 / 33卷 / 13期

基金：

美国国家卫生研究院;

关键词：

aphasia; brain health; connectome; diabetes; stroke; WHITE-MATTER NETWORK; COGNITIVE DECLINE; ANOMIA TREATMENT; WORKING-MEMORY; DISEASE; DAMAGE; CONNECTIVITY; HYPERTENSION; ASSOCIATION; DEFICITS;

D O I：

10.1093/cercor/bhad140

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In post-stroke aphasia, language improvements following speech therapy are variable and can only be partially explained by the lesion. Brain tissue integrity beyond the lesion (brain health) may influence language recovery and can be impacted by cardiovascular risk factors, notably diabetes. We examined the impact of diabetes on structural network integrity and language recovery. Seventy-eight participants with chronic post-stroke aphasia underwent six weeks of semantic and phonological language therapy. To quantify structural network integrity, we evaluated the ratio of long-to-short-range white matter fibers within each participant's whole brain connectome, as long-range fibers are more susceptible to vascular injury and have been linked to high level cognitive processing. We found that diabetes moderated the relationship between structural network integrity and naming improvement at 1 month post treatment. For participants without diabetes (n = 59), there was a positive relationship between structural network integrity and naming improvement (t = 2.19, p = 0.032). Among individuals with diabetes (n = 19), there were fewer treatment gains and virtually no association between structural network integrity and naming improvement. Our results indicate that structural network integrity is associated with treatment gains in aphasia for those without diabetes. These results highlight the importance of post-stroke structural white matter architectural integrity in aphasia recovery.

引用

页码：8557 / 8564

页数：8

共 70 条

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