Advances in free fatty acid profiles in gestational diabetes mellitus

被引：8
作者：
Du, Haoyi [1 ]
Li, Danyang [1 ]
Molive, Laura Monjowa [1 ]
Wu, Na [1 ,2 ]
机构：
[1] China Med Univ, Shengjing Hosp, Dept Endocrinol, Shenyang 110004, Peoples R China
[2] China Med Univ, Shengjing Hosp, Med Dept, Shenyang, Liaoning Provin, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2024年 / 22卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Gestational diabetes mellitus; Free fatty acids; Dietary; Fetal growth; Pregnancy outcomes; PREGNANT-WOMEN; DOCOSAHEXAENOIC ACID; DIETARY-FAT; INSULIN-RESISTANCE; LIPOPROTEIN-LIPASE; MATERNAL LIPIDS; NEONATES BORN; GLUCOSE; METABOLISM; SUPPLEMENTATION;
D O I：
10.1186/s12967-024-04922-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The morbidity of gestational diabetes mellitus (GDM) is increasing and is associated with adverse perinatal outcomes and long-term maternal and infant health. The exact mechanism underlying changes in plasma free fatty acid (FFA) profiles in patients with GDM is unknown. However, it is believed that changes in diet and lipid metabolism may play a role. Fatty acids contain many specific FFAs, and the type of FFA has different impacts on physiological processes; hence, determining changes in FFAs in individual plasma is essential. Alterations in FFA concentration or profile may facilitate insulin resistance. Additionally, some FFAs show potential to predict GDM in early pregnancy and are strongly associated with the growth and development of the fetus and occurrence of macrosomia. Here, we aimed to review changes in FFAs in women with GDM and discuss the relationship of FFAs with GDM incidence and adverse outcomes.
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页数：12
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