Overcoming challenges in the delivery of STING agonists for cancer immunotherapy: A comprehensive review of strategies and future perspectives

被引：42
作者：
Huang, Cuiqing [1 ,2 ]
Shao, Ni [1 ]
Huang, Yanyu [3 ]
Chen, Jifeng [1 ]
Wang, Duo [1 ]
Hu, Genwen [1 ,4 ]
Zhang, Hong [5 ]
Luo, Liangping [1 ]
Xiao, Zeyu [1 ]
机构：
[1] Jinan Univ, Affiliated Hosp 1, Guangzhou Key Lab Mol & Funct Imaging Clin Transla, Guangzhou 510632, Peoples R China
[2] Guangdong Women & Children Hosp, Dept Ultrasound, Guangzhou 511400, Peoples R China
[3] Univ Calif Davis, Dept Biochem & Mol Med, Sacramento, CA 95817 USA
[4] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Radiol, Shenzhen 518020, Peoples R China
[5] Jinan Univ, Affiliated Hosp 6, Dept Intervent Vasc Surg, Dongguan 523560, Peoples R China
来源：
MATERIALS TODAY BIO | 2023年 / 23卷
关键词：
STING agonists; Nanoprecipitation; Self; -assembly; Hydrogel; Cancer immunotherapy; TUMOR MICROENVIRONMENT; BIODEGRADABLE HYDROGELS; CYCLIC DINUCLEOTIDE; CONTROLLED-RELEASE; IMMUNE AGONISTS; INNATE IMMUNITY; NANOPARTICLES; COMBINATION; THERAPY; CELLS;
D O I：
10.1016/j.mtbio.2023.100839
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
STING (Stimulator of Interferon Genes) agonists have emerged as promising agents in the field of cancer immunotherapy, owing to their excellent capacity to activate the innate immune response and combat tumorinduced immunosuppression. This review provides a comprehensive exploration of the strategies employed to develop effective formulations for STING agonists, with particular emphasis on versatile nano-delivery systems. The recent advancements in delivery systems based on lipids, natural/synthetic polymers, and proteins for STING agonists are summarized. The preparation methodologies of nanoprecipitation, self-assembly, and hydrogel, along with their advantages and disadvantages, are also discussed. Furthermore, the challenges and opportunities in developing next-generation STING agonist delivery systems are elaborated. This review aims to serve as a reference for researchers in designing novel and effective STING agonist delivery systems for cancer immunotherapy.
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页数：18
相关论文
共 207 条
[1]   Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages [J].
Akao, Yukihiro ;
Iio, Akio ;
Itoh, Tomohiro ;
Noguchi, Shunsuke ;
Itoh, Yuko ;
Ohtsuki, Yoshinori ;
Naoe, Tomoki .
MOLECULAR THERAPY, 2011, 19 (02) :395-399
[2]   Current and Future Prospective of Injectable Hydrogels-Design Challenges and Limitations [J].
Almawash, Saud ;
Osman, Shaaban K. ;
Mustafa, Gulam ;
El Hamd, Mohamed A. .
PHARMACEUTICALS, 2022, 15 (03)
[3]   Technical aspects of preparing PEG-PLGA nanoparticles as carrier for chemotherapeutic agents by nanoprecipitation method [J].
Almoustafa, Hassan A. ;
Alshawsh, Mohammed A. ;
Chik, Zamri .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 533 (01) :275-284
[4]   STING Agonists as Cancer Therapeutics [J].
Amouzegar, Afsaneh ;
Chelvanambi, Manoj ;
Filderman, Jessica N. ;
Storkus, Walter J. ;
Luke, Jason J. .
CANCERS, 2021, 13 (11)
[5]   Induction of necrotic cell death and activation of STING in the tumor microenvironment via cationic silica nanoparticles leading to enhanced antitumor immunity [J].
An, Myunggi ;
Yu, Chunsong ;
Xi, Jingchao ;
Reyes, Joyce ;
Mao, Guangzhao ;
Wei, Wei-Zen ;
Liu, Haipeng .
NANOSCALE, 2018, 10 (19) :9311-9319
[6]   Intratumoral Delivery of Immunotherapy-Act Locally, Think Globally [J].
Angela Aznar, M. ;
Tinari, Nicola ;
Rullan, Antonio J. ;
Sanchez-Paulete, Alfonso R. ;
Rodriguez-Ruiz, Maria E. ;
Melero, Ignacio .
JOURNAL OF IMMUNOLOGY, 2017, 198 (01) :31-39
[7]  
[Anonymous], 2021, Biomater. Sci., V9, P4904, DOI [10.1039/d1bm00568-,4904-4921, DOI 10.1039/D1BM00568-,4904-4921]
[8]   Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1 [J].
Aroh, Chukwuemika ;
Wang, Zhaohui ;
Dobbs, Nicole ;
Luo, Min ;
Chen, Zhijian ;
Gao, Jinming ;
Yan, Nan .
JOURNAL OF IMMUNOLOGY, 2017, 199 (11) :3840-3848
[9]   Dual agonist immunostimulatory nanoparticles combine with PD1 blockade for curative neoadjuvant immunotherapy of aggressive cancers [J].
Atukorale, Prabhani U. ;
Moon, Taylor J. ;
Bokatch, Alexandr R. ;
Lusi, Christina F. ;
Routhier, Jackson T. ;
Deng, Victoria J. ;
Karathanasis, Efstathios .
NANOSCALE, 2022, 14 (04) :1144-1159
[10]   Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity [J].
Atukorale, Prabhani U. ;
Raghunathan, Shruti P. ;
Raguveer, Vanitha ;
Moon, Taylor J. ;
Zheng, Carolyn ;
Bielecki, Peter A. ;
Wiese, Michelle L. ;
Goldberg, Amy L. ;
Covarrubias, Gil ;
Hoimes, Christopher J. ;
Karathanasis, Efstathios .
CANCER RESEARCH, 2019, 79 (20) :5394-5406
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