Preclinical models and evaluation criteria of prostatitis

被引:16
作者
He, Hailan [1 ,2 ]
Luo, Hui [1 ,2 ]
Xu, Hui [2 ,3 ,4 ]
Qian, Biao [2 ,3 ,4 ]
Zou, Xiaofeng [2 ,3 ,4 ]
Zhang, Guoxi [2 ,3 ,4 ]
Zeng, Fei [1 ]
Zou, Junrong [2 ,3 ,4 ]
机构
[1] Gannan Med Univ, Clin Coll 1, Ganzhou, Jiangxi, Peoples R China
[2] Gannan Med Univ, Dept Urol, Affiliated Hosp 1, Ganzhou, Jiangxi, Peoples R China
[3] Gannan Med Univ, Inst Urol, Affiliated Hosp 1, Ganzhou, Jiangxi, Peoples R China
[4] Jiangxi Engn Technol Res Ctr Calculi Prevent, Dept Urol, Ganzhou, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
prostatitis; chronic non-bacterial prostatitis; animal models; evaluation criteria; infectious prostatitis; EXPERIMENTAL AUTOIMMUNE PROSTATITIS; PELVIC PAIN SYNDROME; STEROID-BINDING PROTEIN; MALE ACCESSORY-GLANDS; LIPID-PEROXIDATION STATUS; SUPPRESSOR T-CELLS; RAT MODEL; MOUSE MODEL; NONBACTERIAL PROSTATITIS; BACTERIAL PROSTATITIS;
D O I
10.3389/fimmu.2023.1183895
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Prostatitis is a common urological condition that affects almost half of all men at some point in their life. The prostate gland has a dense nerve supply that contributes to the production of fluid to nourish sperm and the mechanism to switch between urination and ejaculation. Prostatitis can cause frequent urination, pelvic pain, and even infertility. Long-term prostatitis increases the risk of prostate cancer and benign prostate hyperplasia. Chronic non-bacterial prostatitis presents a complex pathogenesis, which has challenged medical research. Experimental studies of prostatitis require appropriate preclinical models. This review aimed to summarize and compare preclinical models of prostatitis based on their methods, success rate, evaluation, and range of application. The objective of this study is to provide a comprehensive understanding of prostatitis and advance basic research.
引用
收藏
页数:18
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