The Microbiome and Antimicrobial Stewardship in Surgical Patients

被引：2

作者：

Creel, Joseph P. ^{[1
]}

Maves, Ryan C. ^{[1
,2
,3
]}

机构：

[1] Wake Forest Univ, Sch Med, Dept Internal Med, Sect Infect Dis, Winston Salem, NC USA

[2] Wake Forest Univ, Sch Med, Dept Anesthesiol, Sect Crit Care Med, Winston Salem, NC USA

[3] Wake Forest Baptist Med Ctr, Sect Infect Dis, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA

来源：

SURGICAL INFECTIONS | 2023年 / 24卷 / 03期

关键词：

antimicrobial resistance; antimicrobial stewardship; microbiome; GASTROINTESTINAL MOTILITY; INTESTINAL MICROBIOTA; ANTIBIOTIC-THERAPY; FECAL FLORA; RESISTANT; IMPACT; GUIDELINES; INFECTION; DIFFICILE; EMERGENCE;

D O I：

10.1089/sur.2022.422

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The human microbiome plays a critical role in health and disease. The microbiota of the human body undergoes disruptions in critical illness, in part due to alterations in physiology but also as the result of medical interventions, most notably antimicrobial drug administration. These alterations may lead to a significant dysbiosis, with increased risks of multi-drug-resistant organism-based secondary infections, Clostridioides difficile promotion, and other infection-related complications. Antimicrobial stewardship is a process that seeks to optimize antimicrobial drug prescription, with recent evidence emphasizing shorter courses of therapy, earlier transitions from empiric to pathogen-specific regimens, and enhanced diagnostic testing. Through a combination of prudent stewardship and wise use of diagnostic testing, clinicians can improve outcomes, reduce the risk of antimicrobial resistance, and help improve the integrity of the microbiome.

引用

页码：220 / 225

页数：6

共 57 条

[1] An insight into gut microbiota and its functionalities [J].

Adak, Atanu ;

Khan, Mojibur R. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 76 (03) :473-493

[2] Emergence of Imipenem-Resistant Gram-Negative Bacilli in Intestinal Flora of Intensive Care Patients [J].

Armand-Lefevre, Laurence ;

Angebault, Cecile ;

Barbier, Francois ;

Hamelet, Emilie ;

Defrance, Gilles ;

Ruppe, Etienne ;

Bronchard, Regis ;

Lepeule, Raphael ;

Lucet, Jean-Christophe ;

El Mniai, Assiya ;

Wolff, Michel ;

Montravers, Philippe ;

Plesiat, Patrick ;

Andremont, Antoine .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (03) :1488-1495

[3] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[4] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[5] Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients [J].

Benus, Robin F. ;

Harmsen, Hermie J. ;

Welling, Gjalt W. ;

Spanjersberg, Rob ;

Zijlstra, Jan G. ;

Degener, John E. ;

van der Werf, Tjip S. .

INTENSIVE CARE MEDICINE, 2010, 36 (08) :1394-1402

[6] EFFECT OF MEROPENEM ON THE INTESTINAL MICROFLORA [J].

BERGAN, T ;

NORD, CE ;

THORSTEINSSON, SB .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1991, 10 (06) :524-527

[7] EFFECTS OF HYPERGLYCEMIA ON INTERDIGESTIVE GASTROINTESTINAL MOTILITY IN HUMANS [J].

BJORNSSON, ES ;

URBANAVICIUS, V ;

ELIASSON, B ;

ATTVALL, S ;

SMITH, U ;

ABRAHAMSSON, H .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1994, 29 (12) :1096-1104

[8] Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial [J].

Bougle, Adrien ;

Tuffet, Sophie ;

Federici, Laura ;

Leone, Marc ;

Monsel, Antoine ;

Dessalle, Thomas ;

Amour, Julien ;

Dahyot-Fizelier, Claire ;

Barbier, Francois ;

Luyt, Charles-Edouard ;

Langeron, Olivier ;

Cholley, Bernard ;

Pottecher, Julien ;

Hissem, Tarik ;

Lefrant, Jean-Yves ;

Veber, Benoit ;

Legrand, Matthieu ;

Demoule, Alexandre ;

Kalfon, Pierre ;

Constantin, Jean-Michel ;

Rousseau, Alexandra ;

Simon, Tabassome ;

Foucrier, Arnaud .

INTENSIVE CARE MEDICINE, 2022, 48 (07) :841-849

[9] IMPACT OF CEFPODOXIME PROXETIL AND AMOXICILLIN ON THE NORMAL ORAL AND INTESTINAL MICROFLORA [J].

BRISMAR, B ;

EDLUND, C ;

NORD, CE .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1993, 12 (09) :714-719

[10] Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections [J].

Buchan, Blake W. ;

Windham, Sam ;

Balada-Llasat, Joan-Miquel ;

Leber, Amy ;

Harrington, Amanda ;

Relich, Ryan ;

Murphy, Caitlin ;

Bard, Jennifer Dien ;

Naccache, Samia ;

Ronen, Shira ;

Hopp, Amanda ;

Mahmutoglu, Derya ;

Faron, Matthew L. ;

Ledeboer, Nathan A. ;

Carroll, Amanda ;

Stone, Hannah ;

Akerele, Oluseun ;

Everhart, Kathy ;

Bonwit, Andrew ;

Kwong, Christina ;

Buckner, Rebecca ;

Del Warren ;

Fowler, Randal ;

Chandrasekaran, Sukantha ;

Huse, Holly ;

Campeau, Shelley ;

Humphries, Romney ;

Graue, Corrin ;

Huang, Angela .

JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (07)

← 1 2 3 4 5 6 →