Insights of metal 8-hydroxylquinolinol complexes as the potential anticancer drugs

被引：15

作者：

Zhou, Xiaofeng ^{[1
]}

机构：

[1] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730030, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2023年 / 238卷

关键词：

Anticancer; Complexes; 8-Hydroxyquinoline; Structures; Drugs; Activities; LOW-DIMENSIONAL COMPOUNDS; HIGH ANTITUMOR-ACTIVITY; CRYSTAL-STRUCTURE; PROTEASOME INHIBITORS; DNA INTERACTION; 8-HYDROXYQUINOLINE DERIVATIVES; PLATINUM(II) COMPLEXES; COPPER-COMPLEXES; HIV-1; INTEGRASE; GALLIUM COMPLEX;

D O I：

10.1016/j.jinorgbio.2022.112051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

8-Hydroxyquinoline and its derivatives, which belong to a well-known class of quinoline based drugs with varied biological activities, have been extensively explored for the treatments of cancer, Alzheimer's disease, neuro-degenerative diseases and other life-threatening diseases. In virtue of the existence of bicyclic heterocyclic scaffold, their bidentate chelators can further bind to metal ions via O-and N-donors from 8-hydroxylquinolinol skeletons to yield a variety of metal 8-hydroxylquinolinol complexes appealing as the anticancer drugs with low toxicity, due to their better biological effects and higher anticancer activities than free 8-hydroxylquinolinol ligands and cis-diammine-dichloro-platinum. The present review summarizes the recent developments in the syntheses, crystal structures, and anticancer activities of metal 8-hydroxylquinolinol complexes, attempting to discover a correlation between their structures and anticancer activities, and to provide an evidence for their potential application perspectives. It means to offer the helpful and meaningful guidance for the researchers in the future syntheses of new and highly efficient anticancer metal 8-hydroxylquinolinol complexes based drugs.

引用

页数：20

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