Splenic Rupture Secondary to Amyloidosis: A Case Report and Review of the Literature

被引：1

作者：

Bahmad, Hisham F. ^{[1
,2
]}

Gogola, Samantha ^{[3
]}

Burton, Lorena ^{[4
]}

Alloush, Ferial ^{[1
,2
]}

Cusnir, Mike ^{[5
]}

Schwartz, Michael ^{[5
]}

Howard, Lydia ^{[1
,2
,6
]}

Sriganeshan, Vathany ^{[1
,2
,6
]}

机构：

[1] Mt Sinai Med Ctr, Arkadi M Rywlin M D Dept Pathol, Miami Beach, FL 33140 USA

[2] Mt Sinai Med Ctr, Lab Med, Miami Beach, FL 33140 USA

[3] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL 33199 USA

[4] Mt Sinai Med Ctr, Dept Internal Med, Miami Beach, FL 33140 USA

[5] Mt Sinai Med Ctr, Dept Internal Med, Div Hematol & Oncol, Miami Beach, FL 33140 USA

[6] Florida Int Univ, Herbert Wertheim Coll Med, Dept Pathol, Miami, FL 33199 USA

来源：

HEMATOLOGY REPORTS | 2023年 / 15卷 / 02期

关键词：

spleen; rupture; amyloid light chain; amyloidosis; plasma cell myeloma; case report; review; STEM-CELL TRANSPLANTATION; SPLEEN SECONDARY; G-CSF; PATIENT; MOBILIZATION;

D O I：

10.3390/hematolrep15020038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amyloidosis is a term describing the extracellular deposit of fibrils composed of subunits of several different normal serum proteins in various tissues. Amyloid light chain (AL) amyloidosis contains fibrils that are composed of fragments of monoclonal light chains. Many different disorders and conditions can lead to spontaneous splenic rupture, including AL amyloidosis. We present a case of a 64-year-old woman with spontaneous splenic rupture and hemorrhage. A final diagnosis of systemic amyloidosis secondary to plasma cell myeloma was made with infiltrative cardiomyopathy and possible diastolic congestive heart failure exacerbation. We also provide a narrative review of all documented cases of splenic rupture associated with amyloidosis from the year 2000 until January 2023, along with the main clinical findings and management strategies.

引用

页码：370 / 383

页数：14

共 29 条

[1] The workings of the amyloid diseases [J].