Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus

被引：20

作者：

Azarova, Iuliia ^{[1
,2
]}

Polonikov, Alexey ^{[3
,4
]}

Klyosova, Elena ^{[2
]}

机构：

[1] Kursk State Med Univ, Dept Biol Chem, 3 Karl Marx St, Kursk 305041, Russia

[2] Kursk State Med Univ, Res Inst Genet & Mol Epidemiol, Lab Biochem Genet & Metabol, 18 Yamskaya St, Kursk 305041, Russia

[3] Kursk State Med Univ, Res Inst Genet & Mol Epidemiol, Lab Stat Genet & Bioinformat, 18 Yamskaya St, Kursk 305041, Russia

[4] Kursk State Med Univ, Dept Biol Med Genet & Ecol, 3 Karl Marx St, Kursk 305041, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期

基金：

俄罗斯科学基金会;

关键词：

type; 2; diabetes; genetic susceptibility; molecular mechanisms; oxidative stress; redox homeostasis; glutathione metabolism; antioxidant enzymes; oxidative enzymes; single nucleotide polymorphism; GAMMA-GLUTAMYL-TRANSFERASE; GENOME-WIDE ASSOCIATION; BETA-CELL FAILURE; STIMULATED INSULIN-SECRETION; HIGH-FAT DIET; OXIDATIVE STRESS; ADIPOSE-TISSUE; GLUTATHIONE METABOLISM; MITOCHONDRIAL DYSFUNCTION; POLYMORPHIC VARIANTS;

D O I：

10.3390/ijms24054738

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review summarizes the current state of the art advances in understanding the role of abnormal redox homeostasis in the molecular mechanisms of T2D and provides comprehensive information on the characteristics and biological functions of antioxidant and oxidative enzymes, as well as discusses genetic studies conducted so far in order to investigate the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis.

引用

页数：36

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