Novel microneedle platforms for the treatment of wounds by drug delivery: A review

被引：20

作者：

An, Heng ^{[1
]}

Gu, Zhen ^{[1
]}

Huang, Zhe ^{[1
]}

Huo, Tong ^{[1
]}

Xu, Yongxiang ^{[3
]}

Dong, Yaozhong ^{[2
]}

Wen, Yongqiang ^{[1
]}

机构：

[1] Univ Sci & Technol Beijing, Daxing Res Inst, Sch Chem & Biol Engn, Beijing Key Lab Bioengn & Sensing Technol, Beijing 100083, Peoples R China

[2] Yantai Yuhuangding Hosp, Yantai 264000, Peoples R China

[3] Peking Univ Sch & Hosp Stomatol, Dept Dent Mat, Beijing 100081, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2024年 / 233卷

基金：

中国国家自然科学基金;

关键词：

Microneedle platforms; Microneedle type; Drug delivery; Wound repair; Wound monitoring; TRANSDERMAL DELIVERY; COATED MICRONEEDLES; PATCH; SKIN; ARRAY; ANTIBACTERIAL; RELEASE; ALPHA; PAIN;

D O I：

10.1016/j.colsurfb.2023.113636

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The management and treatment of wounds are complex and pose a substantial financial burden to the patient. However, the complex environment of wounds leads to inadequate drug absorption to achieve the desired therapeutic effect. As a novel technological platform, microneedles are widely used in drug delivery because of their multiple drug loading, multistage drug release, and multiple designs of topology. This study systematically summarizes and analyzes the manufacturing methods and limitations of different microneedles, as well as the latest research advances in pain management, drug delivery, and healing promotion, and presents the challenges and opportunities for clinical applications. On this basis, the development of microneedles in external wound repair and management is envisioned, and it is hoped that this study can provide guidelines for the design of microneedle systems in different application contexts, including the selection of materials, preparation methods, and structural design, to achieve better healing and regeneration results.

引用

页数：14

共 148 条

[81] A combined approach of hollow microneedles and nanocarriers for skin immunization with plasmid DNA encoding ovalbumin [J].