Exploring Key Biomarkers and Common Pathogenesis of Seven Digestive System Cancers and Their Correlation with COVID-19

被引：3

作者：

Xiong, Zuming ^{[1
]}

Yang, Yongjun ^{[1
]}

Li, Wenxin ^{[1
]}

Lin, Yirong ^{[1
]}

Huang, Wei ^{[1
]}

Zhang, Sen ^{[1
]}

机构：

[1] Guangxi Med Univ, Dept Colorectal & Anal Surg, Affiliated Hosp 1, Nanning 530021, Peoples R China

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2023年 / 45卷 / 07期

基金：

中国国家自然科学基金; 英国科研创新办公室;

关键词：

digestive system cancers; COVID-19; common biomarkers; pathogenesis; diagnosis; prognosis; PROLIFERATION; CARCINOMA; SEQUELAE;

D O I：

10.3390/cimb45070349

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Digestive system cancer and COVID-19 significantly affect the digestive system, but the mechanism of interaction between COVID-19 and the digestive system cancers has not been fully elucidated. We downloaded the gene expression of COVID-19 and seven digestive system cancers (oral, esophageal, gastric, colorectal, hepatocellular, bile duct, pancreatic) from GEO and identified hub differentially expressed genes. Multiple verifications, diagnostic efficacy, prognostic analysis, functional enrichment and related transcription factors of hub genes were explored. We identified 23 common DEGs for subsequent analysis. CytoHubba identified nine hub genes (CCNA2, CCNB1, CDKN3, ECT2, KIF14, KIF20A, KIF4A, NEK2, TTK). TCGA and GEO data validated the expression and excellent diagnostic and prognostic ability of hub genes. Functional analysis revealed that the processes of cell division and the cell cycle were essential in COVID-19 and digestive system cancers. Furthermore, six related transcription factors (E2F1, E2F3, E2F4, MYC, TP53, YBX1) were involved in hub gene regulation. Via in vitro experiments, CCNA2, CCNB1, and MYC expression was verified in 25 colorectal cancer tissue pairs. Our study revealed the key biomarks and common pathogenesis of digestive system cancers and COVID-19. These may provide new ideas for further mechanistic research.

引用

页码：5515 / 5533

页数：19

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