Current perspectives of mitochondria-targeted antioxidants in cancer prevention and treatment

被引：19

作者：

Zinovkin, Roman A. A. ^{[1
,2
]}

Lyamzaev, Konstantin G. G. ^{[1
,2
]}

Chernyak, Boris V. V. ^{[1
]}

机构：

[1] Lomonosov Moscow State Univ, Belozersky Inst Phys Chem Biol, Moscow, Russia

[2] Pirogov Russian Natl Res Med Univ, Russian Clin Res Ctr Gerontol, Minist Healthcare Russian Federat, Moscow, Russia

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

关键词：

cancer development; oxidative stress; mitochondrial ROS; mitochondria-targeted antioxidants; cancer therapy; EPITHELIAL-MESENCHYMAL TRANSITION; FACTOR-KAPPA-B; TRANSCRIPTION FACTOR NRF2; PLASTOQUINONE DERIVATIVES; INTERRUPT EXECUTION; OXIDATIVE STRESS; INDUCED APOPTOSIS; CERVICAL-CANCER; ASCORBIC-ACID; GS-NITROXIDE;

D O I：

10.3389/fcell.2023.1048177

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oxidative stress nearly always accompanies all stages of cancer development. At the early stages, antioxidants may help to reduce reactive oxygen species (ROS) production and exhibit anticarcinogenic effects. In the later stages, ROS involvement becomes more complex. On the one hand, ROS are necessary for cancer progression and epithelial-mesenchymal transition. On the other hand, antioxidants may promote cancer cell survival and may increase metastatic frequency. The role of mitochondrial ROS in cancer development remains largely unknown. This paper reviews experimental data on the effects of both endogenous and exogenous antioxidants on cancerogenesis focusing on the development and application of mitochondria-targeted antioxidants. We also discuss the prospects for antioxidant cancer therapy, focusing on the use of mitochondria-targeted antioxidants.

引用

页数：15

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