Racing CARs to veterinary immuno-oncology

被引:0
作者
Cockey, James R. [1 ]
Leifer, Cynthia A. [1 ]
机构
[1] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14850 USA
关键词
applied immunology; cancer; cell therapy; immunotherapy; translational medicine; NATURAL-KILLER-CELLS; DELTA T-CELLS; NK CELLS; SAFETY SWITCH; IN-VIVO; CANINE; THERAPY; EXPRESSION; EXPANSION; MURINE;
D O I
10.3389/fvets.2023.1130182
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Chimeric antigen receptors (CARs) have demonstrated remarkable promise in human oncology over the past two decades, yet similar strategies in veterinary medicine are still in development. CARs are synthetically engineered proteins comprised of a specific antigen-binding single chain variable fragment (ScFv) fused to the signaling domain of a T cell receptor and co-receptors. Patient T cells engineered to express a CAR are directed to recognize and kill target cells, most commonly hematological malignancies. The U.S Food and Drug Administration (FDA) has approved multiple human CAR T therapies, but translation of these therapies into veterinary medicine faces many challenges. In this review, we discuss considerations for veterinary use including CAR design and cell carrier choice, and discuss the future promise of translating CAR therapy into veterinary oncology.
引用
收藏
页数:8
相关论文
共 123 条
  • [21] The SIRPα-CD47 immune checkpoint in NK cells
    Deuse, Tobias
    Hu, Xiaomeng
    Agbor-Enoh, Sean
    Jang, Moon K.
    Alawi, Malik
    Saygi, Ceren
    Gravina, Alessia
    Tediashvili, Grigol
    Nguyen, Vinh Q.
    Liu, Yuan
    Valantine, Hannah
    Lanier, Lewis L.
    Schrepfer, Sonja
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218 (03)
  • [22] Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
    Di Stasi, Antonio
    Tey, Siok-Keen
    Dotti, Gianpietro
    Fujita, Yuriko
    Kennedy-Nasser, Alana
    Martinez, Caridad
    Straathof, Karin
    Liu, Enli
    Durett, April G.
    Grilley, Bambi
    Liu, Hao
    Cruz, Conrad R.
    Savoldo, Barbara
    Gee, Adrian P.
    Schindler, John
    Krance, Robert A.
    Heslop, Helen E.
    Spencer, David M.
    Rooney, Cliona M.
    Brenner, Malcolm K.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (18) : 1673 - 1683
  • [23] Dudley ME, 2002, SCIENCE, V298, P850, DOI 10.1126/science.1076514
  • [24] Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients
    Dudley, ME
    Wunderlich, JR
    Shelton, TE
    Even, J
    Rosenberg, SA
    [J]. JOURNAL OF IMMUNOTHERAPY, 2003, 26 (04): : 332 - 342
  • [25] Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
    Eyquem, Justin
    Mansilla-Soto, Jorge
    Giavridis, Theodoros
    van der Stegen, Sjoukje J. C.
    Hamieh, Mohamad
    Cunanan, Kristen M.
    Odak, Ashlesha
    Goenen, Mithat
    Sadelain, Michel
    [J]. NATURE, 2017, 543 (7643) : 113 - +
  • [26] A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors
    Fierle, Julie K.
    Abram-Saliba, Johan
    Atsaves, Vasileios
    Brioschi, Matteo
    de Tiani, Mariastella
    Reichenbach, Patrick
    Irving, Melita
    Coukos, George
    Dunn, Steven M.
    [J]. SCIENTIFIC REPORTS, 2022, 12 (01)
  • [27] NCR1 Expression Identifies Canine Natural Killer Cell Subsets with Phenotypic Similarity to Human Natural Killer Cells
    Foltz, Jennifer A.
    Somanchi, Srinivas S.
    Yang, Yanwen
    Aquino-Lopez, Arianexys
    Bishop, Erin E.
    Lee, Dean A.
    [J]. FRONTIERS IN IMMUNOLOGY, 2016, 7
  • [28] LIPOSOME-ENCAPSULATED MURAMYL TRIPEPTIDE PHOSPHATIDYLETHANOLAMINE FOR THE TREATMENT OF FELINE MAMMARY ADENOCARCINOMA - A MULTICENTER RANDOMIZED DOUBLE-BLIND-STUDY
    FOX, LE
    MACEWEN, EG
    KURZMAN, ID
    DUBIELZIG, RR
    HELFAND, SC
    VAIL, DM
    KISSEBERTH, W
    LONDON, C
    MADEWELL, BR
    RODRIGUEZ, CO
    JEGLUM, KA
    ROSENBERG, M
    ROSENTHAL, RC
    [J]. CANCER BIOTHERAPY, 1995, 10 (02): : 125 - 130
  • [29] FRANK KB, 1984, J BIOL CHEM, V259, P1566
  • [30] Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis
    Fraser, Alasdair R.
    Pass, Chloe
    Burgoyne, Paul
    Atkinson, Anne
    Bailey, Laura
    Laurie, Audrey
    McGowan, Neil W. A.
    Hamid, Akib
    Moore, Joanna K.
    Dwyer, Benjamin J.
    Turner, Marc L.
    Forbes, Stuart J.
    Campbell, John D. M.
    [J]. CYTOTHERAPY, 2017, 19 (09) : 1113 - 1124