Protein arginine methyltransferases in renal development, injury, repair, and fibrosis

被引：2

作者：

Yu, Jianjun ^{[1
]}

Yu, Chao ^{[1
]}

Bayliss, Georgia ^{[2
,3
]}

Zhuang, Shougang ^{[1
,2
,3
]}

机构：

[1] Tongji Univ, Shanghai East Hosp, Dept Nephrol, Sch Med, Shanghai, Peoples R China

[2] Brown Univ, Rhode Isl Hosp, Dept Med, Providence, RI 02912 USA

[3] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

protein arginine methyltransferases; methylation; post-translational modifications; renal development; injury; repair; kidney; fibrosis; ASYMMETRIC DIMETHYLARGININE; MOLECULAR-MECHANISMS; BLOOD-PRESSURE; 7; PRMT7; KIDNEY; METHYLATION; EXPRESSION; CELLS; ADMA; IDENTIFICATION;

D O I：

10.3389/fphar.2023.1123415

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Protein arginine methyltransferases (PRMTs) methylate a range of histone and non-histone substrates and participate in multiple biological processes by regulating gene transcription and post-translational modifications. To date, most studies on PRMTs have focused on their roles in tumors and in the physiological and pathological conditions of other organs. Emerging evidence indicates that PRMTs are expressed in the kidney and contribute to renal development, injury, repair, and fibrosis. In this review, we summarize the role and the mechanisms of PRMTs in regulating these renal processes and provide a perspective for future clinical applications.

引用

页数：9

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