Clinical utility of the carcinoembryonic antigen level in patients with stage III colon cancer after surgery and adjuvant chemotherapy

被引：1

作者：

Udagawa, Shohei ^{[1
]}

Osumi, Hiroki ^{[1
]}

Kozuki, Ryotaro ^{[2
]}

Ooki, Akira ^{[1
]}

Wakatsuki, Takeru ^{[1
]}

Kurihara, Nozomi ^{[3
]}

Mukai, Toshiki ^{[2
]}

Yamaguchi, Tomohiro ^{[2
]}

Akiyoshi, Takashi ^{[2
]}

Fukunaga, Yosuke ^{[2
]}

Yamaguchi, Kensei ^{[1
]}

Shinozaki, Eiji ^{[1
]}

机构：

[1] Japanese Fdn Canc Res, Dept Gastroenterol Chemotherapy, Canc Inst Hosp, Tokyo 1358550, Japan

[2] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Gastroenterol Surg, Tokyo 1358550, Japan

[3] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Clin Trial Planning & Strategy, Tokyo 1358550, Japan

来源：

SURGERY TODAY | 2024年 / 54卷 / 07期

关键词：

Carcinoembryonic antigen; Colonic neoplasms; Postoperative period; Recurrence; Risk; FOLLOW-UP; PRACTICE GUIDELINES; CURATIVE RESECTION; RECURRENCE; ASSOCIATION; METASTASES; DIAGNOSIS; ACCURACY; VALUES; CEA;

D O I：

10.1007/s00595-023-02779-6

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PurposeThe association between perioperative and post-adjuvant carcinoembryonic antigen (CEA) levels and recurrence and prognosis remains unclear. We aimed to evaluate whether perioperative CEA levels are an integral component of the assessment of recurrence and prognosis of patients with stage III colon cancer (CC).MethodsThis retrospective study was conducted at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research from 2005 to 2013. We enrolled patients with stage III CC who underwent complete resection of a primary tumor and received adjuvant chemotherapy. We analyzed the association between perioperative and post-adjuvant CEA levels and recurrence-free survival (RFS) and overall survival (OS).ResultsA total of 564 consecutive patients were included in the analysis. The RFS and OS of patients with high postoperative CEA levels were significantly worse than those of patients with normal postoperative CEA levels. In the multivariate analysis, high postoperative CEA levels were associated with shorter RFS and OS. The number of risk factors, postoperative CEA levels, and T/N-stage all had a cumulative effect on RFS and OS.ConclusionsHigh postoperative CEA levels and the number of risk factors are associated with recurrence and worse prognosis for patients with stage III CC.

引用

页码：692 / 701

页数：10

共 38 条

[1] Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].

Argiles, G. ;

Tabernero, J. ;

Labianca, R. ;

Hochhauser, D. ;

Salazar, R. ;

Iveson, T. ;

Laurent-Puig, P. ;

Quirke, P. ;

Yoshino, T. ;

Taieb, J. ;

Martinelli, E. ;

Arnold, D. .

ANNALS OF ONCOLOGY, 2020, 31 (10) :1291-1305

[2] Association of post-operative CEA with survival and oxaliplatin benefit in patients with stage II colon cancer: a post hoc analysis of the MOSAIC trial [J].

Auclin, Edouard ;

Andre, Thierry ;

Taieb, Julien ;

Banzi, Maria ;

Van Laethem, Jean-Luc ;

Tabernero, Josep ;

Hickish, Tamas ;

de Gramont, Aimery ;

Vernerey, Dewi .

BRITISH JOURNAL OF CANCER, 2019, 121 (04) :312-317

[3] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[4] Intensive follow-up after liver resection for colorectal liver metastases: results of combined serial tumour marker estimations and computed tomography of the chest and abdomen - a prospective study [J].

Bhattacharjya, S. ;

Aggarwal, R. ;

Davidson, B. R. .

BRITISH JOURNAL OF CANCER, 2006, 95 (01) :21-26

[5]

Choi Jin Sub, 1997, Yonsei Medical Journal, V38, P1

[6] Microsatellite Instability in Patients With Stage III Colon Cancer Receiving Fluoropyrimidine With or Without Oxaliplatin: An ACCENT Pooled Analysis of 12 Adjuvant Trials [J].

Cohen, Romain ;

Taieb, Julien ;

Fiskum, Jack ;

Yothers, Greg ;

Goldberg, Richard ;

Yoshino, Takayuki ;

Alberts, Steven ;

Allegra, Carmen ;

de Gramont, Aimery ;

Seitz, Jean-Francois ;

O'Connell, Michael ;

Haller, Daniel ;

Wolmark, Norman ;

Erlichman, Charles ;

Zaniboni, Alberto ;

Lonardi, Sara ;

Kerr, Rachel ;

Grothey, Axel ;

Sinicrope, Frank A. ;

Andre, Thierry ;

Shi, Qian .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (06) :642-+

[7] Prognostic value of circulating tumor DNA in patients with colon cancer: Systematic review [J].

Fan, Gaowei ;

Zhang, Kuo ;

Yang, Xin ;

Ding, Jiansheng ;

Wang, Zujian ;

Li, Jinming .

PLOS ONE, 2017, 12 (02)

[8] DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES [J].

GOLD, P ;

FREEDMAN, SO .

JOURNAL OF EXPERIMENTAL MEDICINE, 1965, 121 (03) :439-+

[9] SPECIFIC CARCINOEMBRYONIC ANTIGENS OF HUMAN DIGESTIVE SYSTEM [J].

GOLD, P ;

FREEDMAN, SO .

JOURNAL OF EXPERIMENTAL MEDICINE, 1965, 122 (03) :467-&

[10] Duration of Adjuvant Chemotherapy for Stage III Colon Cancer [J].

Grothey, A. ;

Sobrero, A. F. ;

Shields, A. F. ;

Yoshino, T. ;

Paul, J. ;

Taieb, J. ;

Souglakos, J. ;

Shi, Q. ;

Kerr, R. ;

Labianca, R. ;

Meyerhardt, J. A. ;

Vernerey, D. ;

Yamanaka, T. ;

Boukovinas, I. ;

Meyers, J. P. ;

Renfro, L. A. ;

Niedzwiecki, D. ;

Watanabe, T. ;

Torri, V. ;

Saunders, M. ;

Sargent, D. J. ;

Andre, T. ;

Iveson, T. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (13) :1177-1188

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