Mesenchymal Stem Cell-Derived Exosomes and Their MicroRNAs in Heart Repair and Regeneration

被引：7

作者：

Akbar, Nukhba ^{[1
]}

Razzaq, Syeda Saima ^{[1
]}

Salim, Asmat ^{[2
]}

Haneef, Kanwal ^{[1
]}

机构：

[1] Univ Karachi, Dr Zafar H Zaidi Ctr Prote, Karachi 75270, Pakistan

[2] Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2024年 / 17卷 / 03期

关键词：

Cardiovascular diseases; Mesenchymal stem cells; Extracellular vesicles; Exosomes; Heart regeneration; MicroRNA;

D O I：

10.1007/s12265-023-10449-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenchymal stem cells (MSCs) can be differentiated into cardiac, endothelial, and smooth muscle cells. Therefore, MSC-based therapeutic approaches have the potential to deal with the aftermaths of cardiac diseases. However, transplanted stem cells rarely survive in damaged myocardium, proposing that paracrine factors other than trans-differentiation may involve in heart regeneration. Apart from cytokines/growth factors, MSCs secret small, single-membrane organelles named exosomes. The MSC-secreted exosomes are enriched in lipids, proteins, nucleic acids, and microRNA (miRNA). There has been an increasing amount of data that confirmed that MSC-derived exosomes and their active molecule microRNA (miRNAs) regulate signaling pathways involved in heart repair/regeneration. In this review, we systematically present an overview of MSCs, their cardiac differentiation, and the role of MSC-derived exosomes and exosomal miRNAs in heart regeneration. In addition, biological functions regulated by MSC-derived exosomes and exosomal-derived miRNAs in the process of heart regeneration are reviewed.

引用

页码：505 / 522

页数：18

共 172 条

[11] Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases [J].

Bian, Xiaowei ;

Ma, Kui ;

Zhang, Cuiping ;

Fu, Xiaobing .

STEM CELL RESEARCH & THERAPY, 2019, 10 (1)

[12]

Bobis S, 2006, FOLIA HISTOCHEM CYTO, V44, P215

[13] Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents [J].

Boerger, Verena ;

Bremer, Michel ;

Ferrer-Tur, Rita ;

Gockeln, Lena ;

Stambouli, Oumaima ;

Becic, Amina ;

Giebel, Bernd .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (07)

[14] Characterization of nonexpanded mesenchymal progenitor cells from normal adult human bone marrow [J].

Boiret, N ;

Rapatel, C ;

Veyrat-Masson, R ;

Guillouard, L ;

Guérin, JJ ;

Pigeon, P ;

Descamps, S ;

Boisgard, S ;

Berger, MG .

EXPERIMENTAL HEMATOLOGY, 2005, 33 (02) :219-225

[15] Mesenchymal stem cells: Cell therapy and regeneration potential [J].

Brown, Christina ;

McKee, Christina ;

Bakshi, Shreeya ;

Walker, Keegan ;

Hakman, Eryk ;

Halassy, Sophia ;

Svinarich, David ;

Dodds, Robert ;

Govind, Chhabi K. ;

Chaudhry, G. Rasul .

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2019, 13 (09) :1738-1755

[16]

Budoni M, 2013, CELL TRANSPLANT, V22, P369, DOI 10.3727/096368911X582769

[17] Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2 [J].

Burchfield, Jana S. ;

Xie, Min ;

Hill, Joseph A. .

CIRCULATION, 2013, 128 (04) :388-400

[18] Exosomes for Intramyocardial Intercellular Communication [J].

Cervio, Elisabetta ;

Barile, Lucio ;

Moccetti, Tiziano ;

Vassalli, Giuseppe .

STEM CELLS INTERNATIONAL, 2015, 2015

[19] miR-19a/19b improves the therapeutic potential of mesenchymal stem cells in a mouse model of myocardial infarction [J].

Chen, Chengbo ;

Chen, Tianbao ;

Li, Yangyi ;

Xu, Youbang .

GENE THERAPY, 2021, 28 (1-2) :29-37

[20] Bone marrow mesenchymal stem cell-derived exosomes attenuate cardiac hypertrophy and fibrosis in pressure overload induced remodeling [J].

Chen, Fu ;

Li, Xueling ;

Zhao, Jinxuan ;

Geng, Jin ;

Xie, Jun ;

Xu, Biao .

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2020, 56 (07) :567-576

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