Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

被引:14
作者
Anastasi, Emanuela [1 ]
Farina, Antonella [1 ]
Granato, Teresa [2 ]
Colaiacovo, Flavia [1 ]
Pucci, Beatrice [1 ]
Tartaglione, Sara [1 ]
Angeloni, Antonio [1 ]
机构
[1] Sapienza Univ Rome, Dept Expt Med, Viale Regina Elena 324, I-00161 Rome, Italy
[2] Sapienza Univ Rome, Inst Mol Biol & Pathol, Dept Mol Med, CNR IBPM, Viale Regina Elena 324, I-00161 Rome, Italy
关键词
ovarian cancer; HE4; oncogenesis; target therapy; EPIDIDYMIS PROTEIN 4; CELL-PROLIFERATION; TUMOR; RISK; OVEREXPRESSION; DIAGNOSIS; INVASION; HYPOXIA; RECOMMENDATIONS; EPIDEMIOLOGY;
D O I
10.3390/ijms241310479
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.
引用
收藏
页数:14
相关论文
共 97 条
  • [71] HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells
    Ribeiro, J. R.
    Schorl, C.
    Yano, N.
    Romano, N.
    Kim, K. K.
    Singh, R. K.
    Moore, R. G.
    [J]. JOURNAL OF OVARIAN RESEARCH, 2016, 9
  • [72] Tubal ligation, hysterectomy and epithelial ovarian cancer in the New England Case-Control Study
    Rice, Megan S.
    Murphy, Megan A.
    Vitonis, Allison F.
    Cramer, Daniel W.
    Titus, Linda J.
    Tworoger, Shelley S.
    Terry, Kathryn L.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2013, 133 (10) : 2415 - 2421
  • [73] HE4 tumor marker as a predictive factor for lymphatic metastasis in endometrial cancer
    Romera, Andrea Espiau
    Guardiola, Tatiana Cuesta
    Vielba, Marta Benito
    Torralba, Carlos De Bonrostro
    Martin, Pluvio J. Coronado
    Mainar, Laura Baquedano
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2020, 149 (03) : 265 - 268
  • [74] HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression
    Rowswell-Turner, Rachael B.
    Singh, Rakesh K.
    Urh, Anze
    Yano, Naohiro
    Kim, Kyu Kwang
    Khazan, Negar
    Pandita, Ravina
    Sivagnanalingam, Umayal
    Hovanesian, Virginia
    James, Nicole E.
    Ribeiro, Jennifer R.
    Kadambi, Sindhuja
    Linehan, David C.
    Moore, Richard G.
    [J]. JOURNAL OF IMMUNOLOGY, 2021, 206 (10) : 2478 - 2488
  • [75] Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients
    Saffarieh, Elham
    Nassiri, Setare
    Mirmohammadkhani, Majid
    [J]. EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY, 2022, 32 (03)
  • [76] Samborski Alexandra, 2022, Tumour Biol, V44, P205, DOI 10.3233/TUB-220016
  • [77] Schenken R.S., ENDOMETRIOSIS PATHOG
  • [78] Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment
    Schoutrop, Esther
    Moyano-Galceran, Lidia
    Lheureux, Stephanie
    Mattsson, Jonas
    Lehti, Kaisa
    Dahlstrand, Hanna
    Magalhaes, Isabelle
    [J]. SEMINARS IN CANCER BIOLOGY, 2022, 86 : 207 - 223
  • [79] HIF-1α regulates epithelial inflammation by cell autonomous NFκB activation and paracrine stromal remodeling
    Scortegagna, Marzia
    Cataisson, Christophe
    Martin, Rebecca J.
    Hicklin, Daniel J.
    Schreiber, Robert D.
    Yuspa, Stuart H.
    Arbeit, Jeffrey M.
    [J]. BLOOD, 2008, 111 (07) : 3343 - 3354
  • [80] The Fallopian Tube-Peritoneal Junction: A Potential Site of Carcinogenesis
    Seidman, Jeffrey D.
    Yemelyanova, Anna
    Zaino, Richard J.
    Kurman, Robert J.
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2011, 30 (01) : 4 - 11