Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

被引：27

作者：

Anastasi, Emanuela ^{[1
]}

Farina, Antonella ^{[1
]}

Granato, Teresa ^{[2
]}

Colaiacovo, Flavia ^{[1
]}

Pucci, Beatrice ^{[1
]}

Tartaglione, Sara ^{[1
]}

Angeloni, Antonio ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Expt Med, Viale Regina Elena 324, I-00161 Rome, Italy

[2] Sapienza Univ Rome, Inst Mol Biol & Pathol, Dept Mol Med, CNR IBPM, Viale Regina Elena 324, I-00161 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 13期

关键词：

ovarian cancer; HE4; oncogenesis; target therapy; EPIDIDYMIS PROTEIN 4; CELL-PROLIFERATION; TUMOR; RISK; OVEREXPRESSION; DIAGNOSIS; INVASION; HYPOXIA; RECOMMENDATIONS; EPIDEMIOLOGY;

D O I：

10.3390/ijms241310479

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.

引用

页数：14

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