Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation

被引：9
作者：
Palamarchuk, Anastasia I. I. [1 ]
Kovalenko, Elena I. I. [1 ]
Streltsova, Maria A. A. [1 ]
机构：
[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Ul Miklukho Maklaya 16-10, Moscow 117997, Russia
来源：
BIOMEDICINES | 2023年 / 11卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
telomerase; TERT; telomerase reverse transcriptase; telomeres; gene regulation; stress; cell death; apoptosis; survival; NF-KAPPA-B; MITOCHONDRIAL-DNA DAMAGE; BETA-CATENIN; DOWN-REGULATION; ANTITUMOR-ACTIVITY; DRUG-RESISTANCE; CANCER-CELLS; IN-VITRO; T-CELL; APOPTOSIS;
D O I：
10.3390/biomedicines11041091
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse transcription of RNA template. Currently, TERT is considered as an intriguing link between multiple signaling pathways. The diverse intracellular localization of TERT corresponds to a wide range of functional activities. In addition to the canonical function of protecting chromosome ends, TERT by itself or as a part of the telomerase complex participates in cell stress responses, gene regulation and mitochondria functioning. Upregulation of TERT expression and increased telomerase activity in cancer and somatic cells relate to improved survival and persistence of such cells. In this review, we summarize the data for a comprehensive understanding of the role of TERT in cell death regulation, with a focus on the interaction of TERT with signaling pathways involved in cell survival and stress response.
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页数：20
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共 164 条
  • [1] Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress
    Ahmed, Shaheda
    Passos, Joao F.
    Birket, Matthew J.
    Beckmann, Tina
    Brings, Sebastian
    Peters, Heiko
    Birch-Machin, Mark A.
    von Zglinicki, Thomas
    Saretzki, Gabriele
    [J]. JOURNAL OF CELL SCIENCE, 2008, 121 (07) : 1046 - 1053
  • [2] Non-canonical roles of canonical telomere binding proteins in cancers
    Akincilar, Semih Can
    Chan, Claire Hian Tzer
    Ng, Qin Feng
    Fidan, Kerem
    Tergaonkar, Vinay
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 78 (09) : 4235 - 4257
  • [3] Reactivation of telomerase in cancer
    Akincilar, Semih Can
    Unal, Bilal
    Tergaonkar, Vinay
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2016, 73 (08) : 1659 - 1670
  • [4] Akiyama M, 2002, CANCER RES, V62, P3876
  • [5] What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?
    Albensi, Benedict C.
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019, 7
  • [6] The Small Molecule BIBR1532 Exerts Potential Anti-cancer Activities in Preclinical Models of Feline Oral Squamous Cell Carcinoma Through Inhibition of Telomerase Activity and Down-Regulation of TERT
    Altamura, Gennaro
    degli Uberti, Barbara
    Galiero, Giorgio
    De Luca, Giovanna
    Power, Karen
    Licenziato, Luca
    Maiolino, Paola
    Borzacchiello, Giuseppe
    [J]. FRONTIERS IN VETERINARY SCIENCE, 2021, 7
  • [7] [Anonymous], 2009, CELL COMMUN SIGNAL, DOI DOI 10.1186/1478-811X-7-S1-A57
  • [8] ATM and ATR signaling at a glance
    Awasthi, Poorwa
    Foiani, Marco
    Kumar, Amit
    [J]. JOURNAL OF CELL SCIENCE, 2015, 128 (23) : 4255 - 4262
  • [9] The CD95 type I/type II model
    Barnhart, BC
    Alappat, EC
    Peter, ME
    [J]. SEMINARS IN IMMUNOLOGY, 2003, 15 (03) : 185 - 193
  • [10] Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?
    Behrooz, Amir Barzegar
    Syahir, Amir
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
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