The Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer

被引：80

作者：

An, Jeongshin ^{[1
,2
]}

Kwon, Hyungju ^{[2
]}

Kim, Young Ju ^{[3
,4
]}

机构：

[1] Ewha Womans Univ, Mokdong Hosp, Inst Convergence Med Res, Coll Med, 1071 Anyangcheon ro, Seoul 07985, South Korea

[2] Ewha Womans Univ, Mokdong Hosp, Coll Med, Dept Surg, 1071 Anyangcheon ro, Seoul 07985, South Korea

[3] Ewha Womans Univ, Ewha Med Inst, Dept Obstet & Gynecol, Seoul 07804, South Korea

[4] Ewha Womans Univ, Coll Med, Seoul 07804, South Korea

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Firmicutes; Bacteroides ratio; breast cancer; microbiome; MICROBIOME;

D O I：

10.3390/jcm12062216

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The gut microbiome can reflect the health condition of the entire body. Firmicutes and Bacteroidetes, the major phyla of the colon, can influence diseases related to obesity which are also risk factors for breast cancer. Therefore, the Firmicutes/Bacteroidetes (F/B) ratio was analyzed in patients with breast cancer. Bacterial extracellular vesicles were extracted from the serum of patients with breast cancer and healthy controls. Phyla Firmicutes and Bacteroidetes were analyzed using microbiome sequencing. Prognostic factors for breast cancer and serological test results were analyzed for correlations with the F/B ratio. The F/B ratio was three times lower in patients with breast cancer than in healthy controls. In addition, the risk factor for breast cancer, such as fasting serum glucose, was found to be related to the F/B ratio. The F/B ratio can be used as a risk factor of breast cancer and as a clue to explain underlying mechanisms affecting the development of breast cancer.

引用

页数：12

共 38 条

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