Association of insulin resistance with the accumulation of saturated intramyocellular lipid: A comparison with other fat stores

被引：1

作者：

Azhar, Mueed ^{[1
]}

Watson, Laura P. E. ^{[2
,3
]}

Rolfe, Emanuella De Lucia ^{[4
]}

Ferraro, Michele ^{[1
]}

Carr, Katherine ^{[2
]}

Worsley, Jieniean ^{[2
]}

Boesch, Chris ^{[5
,6
]}

Hodson, Leanne ^{[7
]}

Chatterjee, Krishna K. ^{[2
,3
]}

Kemp, Graham J. ^{[8
]}

Savage, David B. ^{[3
]}

Sleigh, Alison ^{[1
,2
,3
]}

机构：

[1] Univ Cambridge, Wolfson Brain Imaging Ctr, Dept Clin Neurosci, Box 65 Addenbrookes Hosp,Cambridge Biomed Campus, Cambridge CB2 0QQ, England

[2] Cambridge Univ Hosp NHS Fdn Trust, Natl Inst Hlth & Care Res, Cambridge Clin Res Facil, Cambridge, England

[3] Univ Cambridge, Wellcome Trust MRC Inst Metab Sci, Metab Res Labs, Cambridge, England

[4] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England

[5] Univ Bern, Dept Clin Res, Bern, Switzerland

[6] Univ Bern, Dept Radiol AMSM, Bern, Switzerland

[7] Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab OCDEM, NIHR Oxford Biomed Res Ctr, Oxford, England

[8] Univ Liverpool, Dept Musculoskeletal & Ageing Sci, Liverpool, England

来源：

NMR IN BIOMEDICINE | 2024年 / 37卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

adipose tissue; ectopic; insulin resistance; intramyocellular lipid; saturation; MEDICAL IMAGE SEGMENTATION; BRAIN-TUMOR SEGMENTATION; LESION SEGMENTATION; TREATMENT RESPONSE; MRI; DISEASE; CANCER; CONSTRUCTION; CONSISTENCY; RESOURCE;

D O I：

10.1002/nbm.5117

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

It has been shown using proton magnetic resonance spectroscopy (1H MRS) that, in a group of females, whole-body insulin resistance was more closely related to accumulation of saturated intramyocellular lipid (IMCL) than to IMCL concentration alone. This has not been investigated in males. We investigated whether age- and body mass index-matched healthy males differ from the previously reported females in IMCL composition (measured as CH2:CH3) and IMCL concentration (measured as CH3), and in their associations with insulin resistance. We ask whether saturated IMCL accumulation is more strongly associated with insulin resistance than other ectopic and adipose tissue lipid pools and remains a significant predictor when these other pools are taken into account. In this group of males, who had similar overall insulin sensitivity to the females, IMCL was similar between sexes. The males demonstrated similar and even stronger associations of IMCL with insulin resistance, supporting the idea that a marker reflecting the accumulation of saturated IMCL is more strongly associated with whole-body insulin resistance than IMCL concentration alone. However, this marker ceased to be a significant predictor of whole-body insulin resistance after consideration of other lipid pools, which implies that this measure carries no more information in practice than the other predictors we found, such as intrahepatic lipid and visceral adipose tissue. As the marker of saturated IMCL accumulation appears to be related to these two predictors and has a much smaller dynamic range, this finding does not rule out a role for it in the pathogenesis of insulin resistance. The males demonstrated similar and stronger associations of IMCL with insulin resistance as our previously reported females, supporting the idea that markers reflecting the accumulation of saturated IMCL are more strongly associated with whole-body insulin resistance than IMCL concentration alone. Stepwise linear regression revealed intrahepatic lipid and visceral adipose tissue to be significant predictors of whole-body insulin resistance. image

引用

页数：11

共 39 条

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