Novel 1,3,4-Oxadiazole Derivatives of Pyridines: Synthesis, Characterization, and Antimicrobial Screening

被引：0

作者：

Godhani, D. R. ^{[1
]}

Saiyad, A. H. ^{[1
]}

Mehta, J. P. ^{[1
]}

Mehta, U. P. ^{[1
]}

机构：

[1] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem, DST FIST Sponsored Dept, Mahatma Gandhi Campus, Bhavnagar 364002, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 59卷 / 11期

关键词：

1,3,4-oxadiazole; pyridine; antibacterial activity; antifungal activity;

D O I：

10.1134/S1070428023110131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In search for new compounds capable of overcoming antimicrobial resistance, we synthesized a series of previously unknown 1-[(2-aryl-5-(pyridine-4-yl)-1,3,4-oxadiazol-3(2H)-yl]-3-(pyridine-2-yl)prop-2-en-1-ones and assessed their composition and structures using elemental analysis, FTIR, 1H NMR, and 13C NMR spectroscopy, and mass spectrometry. The synthesized compounds were screened for antibacterial activity to show that 1-[2-(3-fluorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl])-3-(pyridin-2-yl)prop-2-en-1-one and 1-[2-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]-3-(pyridin-2-yl)prop-2-en-1-one were effective against C. albicans and A. clavatus fungal strains, while 1-[(2-phenyl-5-(pyridine-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-3-(pyridine-2-yl)prop-2-en-1-one and 1-[2-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]-3-(pyridin-2-yl)prop-2-en-1-one demonstrated activity against E. coli and P. aeruginosa bacterial strains.

引用

页码：1952 / 1960

页数：9

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