Hemodynamic Impact of Snoring on Carotid Artery after Stent Implantation: The Role of Oscillation

被引:1
作者
Zhang, Xianghao [1 ]
Fan, Zhenmin [1 ]
Liu, Xiao [2 ]
Liu, Mingyuan [3 ]
Ye, Xia [1 ]
Deng, Xiaoyan [2 ]
机构
[1] Jiangsu Univ Technol, Sch Mech Engn, Zhenjiang, Jiangsu, Peoples R China
[2] Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Friendship Hosp, Dept Vasc Surg, Beijing Ctr Vasc Surg, Beijing, Peoples R China
基金
国家重点研发计划;
关键词
Snoring; Carotid artery; Stent; Hemodynamics; Numerical study; ENDOTHELIAL SHEAR-STRESS; INTIMA-MEDIA THICKNESS; BLOOD-FLOW; BULK FLOW; RESTENOSIS; THROMBOSIS; BIFURCATION; MODELS; ASSOCIATION; MECHANISM;
D O I
10.37190/ABB-02207-2023-01
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Snoring is common in overweight and old patients treated by endovascular stenting. Studies have proved a correlation between snoring and carotid stenosis, thus, snoring after carotid artery stenting (CAS) might promote or worsen clinical performance. This study tested this hypothesis by constructing a patient-specific carotid bifurcation model and numerically analyzing hemodynamic changes of the carotid artery under different snoring conditions. These conditions included small and large amplitude, low and high frequency, and different age groups. The results found that high amplitude snoring suppressed the disturbed flow at the stented segment, while the downstream region of ICA became more chaotic, accounting for in-stent intimal restenosis and thrombosis. Furthermore, local blood flow patterns of elder groups with snoring symptoms were more likely to be changed due to low-speed flow, increasing the possibility of vascular remodeling and thrombosis. Besides, increased snoring frequency hardly influenced the local disturbed flow. Therefore, older adults should receive medical treatment actively after stenting for high-amplitude snoring as soon as possible to avoid potential adverse events.
引用
收藏
页码:35 / 45
页数:18
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