Advanced parental age affects cardiometabolic risk in offspring

被引：1
作者：
Malamitsi-Puchner, Ariadne [1 ,2 ]
Briana, Despina D. [1 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pediat 3, Neonatal Intens Care Unit, Athens, Greece
[2] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pediat 3, Neonatal Intens Care Unit, Soultani 19, Athens 10682, Greece
来源：
ACTA PAEDIATRICA | 2023年 / 112卷 / 11期
关键词：
advanced parental age; cardio-metabolic disorders; developmental programming; intergenerational inheritance; offspring; ADVANCED MATERNAL AGE; PATERNAL AGE; CHILDBIRTH; BIRTH; PREGNANCY;
D O I：
10.1111/apa.16902
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Advanced age at conception usually refers to human mothers aged 35 years plus and fathers aged 40 years plus. Advanced parental age may be responsible for genetic and/or epigenetic alterations and may affect the health of offspring. Limited epidemiological and experimental studies have addressed the effect of advanced parental age on cardio-metabolic functions in human and rodent offspring. This mini review aimed to present the knowledge by focusing on adverse and favourable outcomes related to sex-specific risks and intergenerational inheritance. The outcomes identified by this review were mainly negative, but there were also some positive results.
引用
收藏
页码：2307 / 2311
页数：5
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