Advanced parental age affects cardiometabolic risk in offspring

被引：0
作者：
Malamitsi-Puchner, Ariadne [1 ,2 ]
Briana, Despina D. [1 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pediat 3, Neonatal Intens Care Unit, Athens, Greece
[2] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pediat 3, Neonatal Intens Care Unit, Soultani 19, Athens 10682, Greece
来源：
ACTA PAEDIATRICA | 2023年 / 112卷 / 11期
关键词：
advanced parental age; cardio-metabolic disorders; developmental programming; intergenerational inheritance; offspring; ADVANCED MATERNAL AGE; PATERNAL AGE; CHILDBIRTH; BIRTH; PREGNANCY;
D O I：
10.1111/apa.16902
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Advanced age at conception usually refers to human mothers aged 35 years plus and fathers aged 40 years plus. Advanced parental age may be responsible for genetic and/or epigenetic alterations and may affect the health of offspring. Limited epidemiological and experimental studies have addressed the effect of advanced parental age on cardio-metabolic functions in human and rodent offspring. This mini review aimed to present the knowledge by focusing on adverse and favourable outcomes related to sex-specific risks and intergenerational inheritance. The outcomes identified by this review were mainly negative, but there were also some positive results.
引用
收藏
页码：2307 / 2311
页数：5
相关论文
共 30 条
  • [1] Paternal age at birth and metabolic risk factors in adolescents: a nationwide survey
    Ahn, H. Y.
    Hwang, I. C.
    [J]. PUBLIC HEALTH, 2019, 175 : 1 - 3
  • [2] Increasing Parental Age at Childbirth is Associated with Greater Insulin Sensitivity and More Favorable Metabolic Profile in Overweight Adult Male Offspring
    Albert, Benjamin B.
    De Bock, Martin
    Derraik, Jose G. B.
    Brennan, Christine M.
    Biggs, Janene B.
    Hofman, Paul L.
    Cutfield, Wayne S.
    [J]. AMERICAN JOURNAL OF HUMAN BIOLOGY, 2015, 27 (03) : 380 - 386
  • [3] The impact of advanced maternal age on pregnancy outcome
    Attali, Emmanuel
    Yogev, Yariv
    [J]. BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2021, 70 : 2 - 9
  • [4] The Implications of Reproductive Aging for the Health, Vitality, and Economic Welfare of Human Societies
    Bhasin, Shalender
    Kerr, Candace
    Oktay, Kutluk
    Racowsky, Catherine
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2019, 104 (09) : 3821 - 3825
  • [5] Maternal Age at Birth and Childhood Type 1 Diabetes: A Pooled Analysis of 30 Observational Studies
    Cardwell, Chris R.
    Stene, Lars C.
    Joner, Geir
    Bulsara, Max K.
    Cinek, Ondrej
    Rosenbauer, Joachim
    Ludvigsson, Johnny
    Jane, Mireia
    Svensson, Jannet
    Goldacre, Michael J.
    Waldhoer, Thomas
    Jarosz-Chobot, Przemyslawa
    Gimeno, Suely G. A.
    Chuang, Lee-Ming
    Parslow, Roger C.
    Wadsworth, Emma J. K.
    Chetwynd, Amanda
    Pozzilli, Paolo
    Brigis, Girts
    Urbonaite, Brone
    Sipetic, Sandra
    Schober, Edith
    Devoti, Gabriele
    Ionescu-Tirgoviste, Constantin
    de Beaufort, Carine E.
    Stoyanov, Denka
    Buschard, Karsten
    Patterson, Chris C.
    [J]. DIABETES, 2010, 59 (02) : 486 - 494
  • [6] Associations of parental age with offspring all-cause and cause-specific adult mortality
    Carslake, David
    Tynelius, Per
    van den Berg, Gerard J.
    Smith, George Davey
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [7] Increased susceptibility to cardiovascular disease in offspring born from dams of advanced maternal age
    Cooke, Christy-Lynn M.
    Shah, Amin
    Kirschenman, Raven D.
    Quon, Anita L.
    Morton, Jude S.
    Care, Alison S.
    Davidge, Sandra T.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2018, 596 (23): : 5807 - 5821
  • [8] Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis
    du Foss, Nadia A.
    Van der Hoorn, Marie-Louise P.
    van Lith, Jan M. M.
    le Cessie, Saskia
    Lashley, Eileen E. L. O.
    [J]. HUMAN REPRODUCTION UPDATE, 2020, 26 (05) : 650 - 669
  • [9] Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review
    Eberle, Claudia
    Kirchner, Michaela F.
    Herden, Raphaela
    Stichling, Stefanie
    [J]. PLOS ONE, 2020, 15 (12):
  • [10] Association between maternal age at childbirth and child and adult outcomes in the off spring: a prospective study in five low-income and middle-income countries (COHORTS collaboration)
    Fall, Caroline H. D.
    Sachdev, Harshpal Singh
    Osmond, Clive
    Restrepo-Mendez, Maria Clara
    Victora, Cesar
    Martorell, Reynaldo
    Stein, Aryeh D.
    Sinha, Shikha
    Tandon, Nikhil
    Adair, Linda
    Bas, Isabelita
    Norris, Shane
    Richter, Linda M.
    [J]. LANCET GLOBAL HEALTH, 2015, 3 (07): : E366 - E377
123