Research Progress in Pharmacological Mechanisms, Structure-Activity Relationship and Synthesis of Sartans

被引：4
作者：
Wang, Ye-Fan [1 ,2 ]
Ren, Xin-Yue [1 ,2 ]
Zhang, Wen [1 ,2 ]
Rao, Guo-Wu [1 ,2 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
[2] Zhejiang Univ Technol, Inst Drug Dev & Chem Biol, Hangzhou 310014, Peoples R China
来源：
CURRENT MEDICINAL CHEMISTRY | 2023年 / 30卷 / 20期
基金：
中国国家自然科学基金;
关键词：
Sartans; AT(1) receptor blocker; renin-angiotensin system; structure-activity relationship; docking with AT(1) receptor; synthesis; II RECEPTOR ANTAGONISTS; BIOLOGICAL EVALUATION; AT1; RECEPTOR; ANTITUMOR EVALUATION; AFFINITY EVALUATION; TYPE-1; ANGIOTENSIN; LOSARTAN; DESIGN; DERIVATIVES;
D O I：
10.2174/0929867329666220829101436
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The sartans are a new class of antihypertensive drugs as angiotensin II receptor blockers which possess plenty of advantages in treating hypertension and related pathologies. This review describes the clinical treatment, side effects, and potential therapeutic effects of sartans from 1995 to date. The synthesis, structural-activity and molecular docking with Angiotensin Type 1 receptor of imidazole derivatives, benzimidazole derivatives and other compounds are also described. With a clear Structure-Activity Relationship and abundant pharmacological effects, some types of novel Angiotensin Type 1 receptor antagonists are emerging gradually for further research in the meantime.
引用
收藏
页码：2247 / 2266
页数：20
相关论文
共 85 条
[1]   The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: A concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives [J].
Agelis, George ;
Resvani, Amalia ;
Durdagi, Serdar ;
Spyridaki, Katerina ;
Tumova, Tereza ;
Slaninova, Jitina ;
Giannopoulos, Panagiotis ;
Vlahakos, Demetrios ;
Liapakis, George ;
Mavromoustakos, Thomas ;
Matsoukas, John .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 :358-374
[2]   Structure-Based Design of hERG-Neutral Antihypertensive Oxazalone and Imidazolone Derivatives (vol 78, pg 240 2017) [J].
Aksoydan, B. ;
Kantarcioglu, I ;
Erol, I ;
Salmas, R. E. ;
Durdagi, S. .
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2017, 77 :240-240
[3]   Angiotensin II receptor antagonist treatment during pregnancy [J].
Alwan, S ;
Polifka, JE ;
Friedman, JM .
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2005, 73 (02) :123-130
[4]   Efficient cobalt-catalyzed formation of unsymmetrical biaryl compounds and its application in the synthesis of a sartan intermediate [J].
Amatore, Muriel ;
Gosmini, Corinne .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (11) :2089-2092
[5]   Manganese-Catalyzed Cross-Coupling of Aryl Halides and Grignard Reagents by a Radical Mechanism [J].
Antonacci, Giuseppe ;
Ahlburg, Andreas ;
Fristrup, Peter ;
Norrby, Per-Ola ;
Madsen, Robert .
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 2017 (32) :4758-4764
[6]  
Bernhart C.B., 1993, US Patent, Patent No. 5270317
[7]   New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: Design, synthesis, and biopharmacological properties [J].
Breschi, MC ;
Calderone, V ;
Digiacomo, M ;
Macchia, M ;
Martelli, A ;
Martinotti, E ;
Minutolo, F ;
Rapposelli, S ;
Rossello, A ;
Testai, L ;
Balsamo, A .
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (08) :2628-2639
[8]   NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE DISCOVERY OF A SERIES OF N-(BIPHENYLYLMETHYL)IMIDAZOLES AS POTENT, ORALLY ACTIVE ANTIHYPERTENSIVES [J].
CARINI, DJ ;
DUNCIA, JV ;
ALDRICH, PE ;
CHIU, AT ;
JOHNSON, AL ;
PIERCE, ME ;
PRICE, WA ;
SANTELLA, JB ;
WELLS, GJ ;
WEXLER, RR ;
WONG, PC ;
YOO, SE ;
TIMMERMANS, PBMWM .
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) :2525-2547
[9]   Tri(1-adamantyl) phosphine: Exceptional Catalytic Effects Enabled by the Synergy of Chemical Stability, Donicity, and Polarizability [J].
Carrow, Brad P. ;
Chen, Liye .
SYNLETT, 2017, 28 (03) :280-288
[10]  
Chakravarty P.K.G., 1992, EP Patent, Patent No. [0505098A1, 0505098]
123456789