Treatment of breakthrough and prevention of refractory chemotherapy-induced nausea and vomiting in pediatric cancer patients: Clinical practice guideline update

被引：9

作者：

Patel, Priya ^{[1
,2
]}

Robinson, Paula D. ^{[1
]}

Phillips, Robert ^{[3
]}

Baggott, Christina ^{[4
]}

Devine, Katie ^{[5
]}

Gibson, Paul ^{[1
,6
]}

Guilcher, Gregory M. T. ^{[7
,8
]}

Holdsworth, Mark T. ^{[9
]}

Neumann, Eloise ^{[10
]}

Orsey, Andrea D. ^{[11
,12
]}

Spinelli, Daniela

Thackray, Jennifer ^{[13
]}

van de Wetering, Marianne ^{[14
]}

Cabral, Sandra

Sung, Lillian ^{[15
,16
]}

Dupuis, L. Lee ^{[2
,16
,17
,18
]}

机构：

[1] Pediat Oncol Grp Ontario, Toronto, ON, Canada

[2] Hosp Sick Children, Dept Pharm, Toronto, ON, Canada

[3] NHS Trust Leeds Teaching Hosp, Dept Haematol & Oncol, Leeds, England

[4] Stanford Canc Inst, Canc Clin Trials Off, Palo Alto, CA USA

[5] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA

[6] McMaster Childrens Hosp, Div Haematol Oncol, Hamilton, ON, Canada

[7] Alberta Childrens Prov Gen Hosp, Sect Paediat Oncol & Blood & Marrow Transplant, Calgary, AB, Canada

[8] Univ Calgary, Dept Oncol & Paediat, Cumming Sch Med, Calgary, AB, Canada

[9] Univ New Mexico, Coll Pharm, Albuquerque, NM USA

[10] Birmingham Womens & Childrens Hosp, Birmingham, England

[11] Connecticut Childrens Med Ctr, Div Pediat Hematol Oncol, Hartford, CT USA

[12] Univ Connecticut, Dept Pediat, Sch Med, Farmington, CT USA

[13] Mem Sloan Kettering Canc Ctr, Dept Pharm, New York, NY USA

[14] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[15] Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON, Canada

[16] Hosp Sick Children, Res Inst, Child Hlth Evaluat Sci, Toronto, ON, Canada

[17] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada

[18] Hosp Sick Children, Res Inst, 555Univ Ave, Toronto, ON M5G1X8, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2023年 / 70卷 / 08期

关键词：

chemotherapy-induced nausea and vomiting; guideline; pediatric oncology; supportive care; ONDANSETRON; OLANZAPINE;

D O I：

10.1002/pbc.30395

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This clinical practice guideline update provides recommendations for treating breakthrough chemotherapy-induced nausea and vomiting (CINV) and preventing refractory CINV in pediatric patients. Two systematic reviews of randomized controlled trials in adult and pediatric patients informed the recommendations. In patients with breakthrough CINV, escalation of antiemetic agents to those recommended for chemotherapy of the next higher level of emetogenic risk is strongly recommended. A similar recommendation to escalate therapy is made to prevent refractory CINV in patients who did not experience complete breakthrough CINV control and are receiving minimally or low emetogenic chemotherapy. A strong recommendation to use antiemetic agents that controlled breakthrough CINV for the prevention of refractory CINV is also made.

引用

页数：11

共 23 条

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