Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in neonatal Hypoxic-Ischaemic encephalopathy

被引：2

作者：

Yang, Liu ^{[1
]}

Zhang, Li ^{[1
]}

Zhu, Jing ^{[1
]}

Wang, Yuqian ^{[1
]}

Zou, Ning ^{[1
]}

Liu, Zhengjuan ^{[1
]}

Wang, Yingjie ^{[1
,2
]}

机构：

[1] Dalian Med Univ, Hosp 2, Dept Pediat, Dalian, Peoples R China

[2] Dalian Med Univ, Hosp 2, Dept Pediat, Dalian 116021, Liaoning, Peoples R China

来源：

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY | 2023年 / 104卷 / 04期

基金：

中国国家自然科学基金;

关键词：

apoptosis; MiR-214-3p; neonatal hypoxic-Ischaemic encephalopathy; neuronal; BRAIN-INJURY; DOWN-REGULATION; MESENCHYMAL TRANSITION; SPINAL-CORD; APOPTOSIS; INHIBITION; CELLS; PROLIFERATION; MIGRATION; PROMOTES;

D O I：

10.1111/iep.12475

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Neonatal hypoxic-ischaemic encephalopathy (HIE) refers to brain damage caused by intra-uterine distress and asphyxia/hypoxia during the perinatal and neonatal periods. MicroRNA (MiR)-214-3p plays a critical role in cell growth and apoptosis. The aim of this study was to investigate the expression and role of miR-214-3p in neonatal HIE development, and to explore the underlying mechanisms. The expression of miR-214-3p was significantly down-regulated, while that of Slc8a1, a direct target of miR-214-3p, was significantly up-regulated, in the brain tissue of neonatal HIE rats. The over-expression of miR-214-3p promoted the proliferation and inhibited the apoptosis of neurones, while its down-regulation had the opposite effect. Our results indicate that miR-214-3p expression was down-regulated in neonatal HIE rats, and the up-regulation of miR-214-3p expression protected against HIE development by inhibiting neuronal apoptosis.

引用

页码：199 / 208

页数：10

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